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    irg-2 Infection Response Gene [ Caenorhabditis elegans ]

    Gene ID: 183619, updated on 9-Dec-2024

    Summary

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    Official Symbol
    irg-2
    Official Full Name
    Infection Response Gene
    Primary source
    WormBase:WBGene00016783
    Locus tag
    CELE_C49G7.5
    See related
    AllianceGenome:WB:WBGene00016783
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in antibacterial innate immune response and defense response to Gram-negative bacterium. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See irg-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (4042181..4043601)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Glycosyltransferase family 17 protein Neighboring gene Anoctamin;Glycosyltransferase family 92 protein Neighboring gene ShKT domain-containing protein Neighboring gene ShKT domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A meta-analysis of RNA-Seq studies to identify novel genes that regulate aging. Bairakdar MD, et al. Exp Gerontol, 2023 Mar. PMID 36731807, Free PMC Article
    2. BLMP-1 is a critical temporal regulator of dietary-restriction-induced response in Caenorhabditis elegans. Hu Q, et al. Cell Rep, 2024 Mar 26. PMID 38483903
    3. Components of the cultivated red seaweed Chondrus crispus enhance the immune response of Caenorhabditis elegans to Pseudomonas aeruginosa through the pmk-1, daf-2/daf-16, and skn-1 pathways. Liu J, et al. Appl Environ Microbiol, 2013 Dec. PMID 24056462, Free PMC Article
    4. bZIP transcription factor zip-2 mediates an early response to Pseudomonas aeruginosa infection in Caenorhabditis elegans. Estes KA, et al. Proc Natl Acad Sci U S A, 2010 Feb 2. PMID 20133860, Free PMC Article
    5. Reprogramming of the transcriptome after heat stress mediates heat hormesis in Caenorhabditis elegans. Xu F, et al. Nat Commun, 2023 Jul 13. PMID 37443152, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in antibacterial innate immune response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in innate immune response HEP PubMed 

    General protein information

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    Preferred Names
    Infection Response Gene
    NP_504128.1
    • Product from WormBase gene class irg;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      4042181..4043601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071727.6 → NP_504128.1  Infection Response Gene [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504128.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16224
    Nucleotide Protein
    Heading Accession and Version

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