tiam-1 DH domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: tiam-1
Official Full Name: DH domain-containing protein
Primary source: WormBase:WBGene00015704
Locus tag: CELE_C11D9.1
See related: AllianceGenome:WB:WBGene00015704
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables guanyl-nucleotide exchange factor activity. Involved in small GTPase-mediated signal transduction. Located in cell periphery and growth cone. Is expressed in gonad; nervous system; and pharynx. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with language delay and seizures. Orthologous to several human genes including TIAM2 (TIAM Rac1 associated GEF 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See tiam-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 18

Sequence:: Chromosome: I; NC_003279.8 (4409689..4426188)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TIAM-1 regulates polarized protrusions during dorsal intercalation in the Caenorhabditis elegans embryo through both its GEF and N-terminal domains.
Title: TIAM-1 regulates polarized protrusions during dorsal intercalation in the Caenorhabditis elegans embryo through both its GEF and N-terminal domains.
Dendrite regeneration in C. elegans is controlled by the RAC GTPase CED-10 and the RhoGEF TIAM-1.
Title: Dendrite regeneration in C. elegans is controlled by the RAC GTPase CED-10 and the RhoGEF TIAM-1.
The experiments suggest that HPO-30/Claudin localizes the DMA-1/LRR-TM receptor on polymodal somatosensory neuron dendrites, which in turn can control dendrite patterning by directly modulating F-actin dynamics through TIAM-1/GEF.
Title: TIAM-1/GEF can shape somatosensory dendrites independently of its GEF activity by regulating F-actin localization.
The delayed aging is mediated by suppressing constitutive endocytosis which alters the subcellular localization of the actin regulator TIAM-1, thereby decreasing age-dependent neurite growth.
Title: A hormone receptor pathway cell-autonomously delays neuron morphological aging by suppressing endocytosis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C11D9.1 (e-PCR)
- UniSTS:313532

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in activation of GTPase activity	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: DH domain-containing protein

NP_491367.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

4409689..4426188

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058966.7 → NP_491367.3 DH domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491367.3

Status: REVIEWED

UniProtKB/TrEMBL

O01847

Conserved Domains (1) summary

cd00160
Location:541 → 715

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.