rpm-1 E3 ubiquitin-protein ligase rpm-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rpm-1
Official Full Name: E3 ubiquitin-protein ligase rpm-1
Primary source: WormBase:WBGene00004457
Locus tag: CELE_C01B7.6
See related: AllianceGenome:WB:WBGene00004457
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables mitogen-activated protein kinase kinase kinase binding activity; protein phosphatase binding activity; and ubiquitin protein ligase activity. Involved in several processes, including negative regulation of intracellular signal transduction; regulation of neuron projection development; and regulation of synapse assembly. Located in axon; neuromuscular junction; and presynaptic periactive zone. Is expressed in coelomocyte; hermaphrodite distal tip cell; nervous system; and pharynx. Orthologous to human MYCBP2 (MYC binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rpm-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 15

Sequence:: Chromosome: V; NC_003283.11 (8805399..8819955, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study reveals an important role for tubulin acetyltransferase activity in presynaptic maintenance, which occurs via the RPM-1/ATAT-2 pathway
Title: Synapse maintenance is impacted by ATAT-2 tubulin acetyltransferase activity and the RPM-1 signaling hub.
E3 ubiquitin-protein ligase rpm-1 (RPM-1) inhibits autophagosome formation to affect axon termination and synapse maintenance.
Title: Autophagy is inhibited by ubiquitin ligase activity in the nervous system.
RPM-1 prevents the overgrowth of the AVG axon by repressing the activity of the DLK-1/p38 Mitogen-Activated Protein Kinase pathway.
Title: RPM-1 and DLK-1 regulate pioneer axon outgrowth by controlling Wnt signaling.
The findings provide insight into how growth cone collapse is regulated during axon termination in vivo, and suggest that RPM-1 signaling destabilizes microtubules to facilitate growth cone collapse and axon termination.
Title: RPM-1 regulates axon termination by affecting growth cone collapse and microtubule stability.
results indicate that RPM-1 uses different mechanisms to recruit FSN-1 and RAE-1 into independent signaling complexes in neurons
Title: Defining Minimal Binding Regions in Regulator of Presynaptic Morphology 1 (RPM-1) Using Caenorhabditis elegans Neurons Reveals Differential Signaling Complexes.
Loss of function in ess-2 suppresses rpm-1 only in the presence of a dlk-1 splice acceptor mutation.
Title: Systematic analyses of rpm-1 suppressors reveal roles for ESS-2 in mRNA splicing in Caenorhabditis elegans.
region of RPM-1 that is sufficient in binding to FSN-1
Title: Identification of a peptide inhibitor of the RPM-1 · FSN-1 ubiquitin ligase complex.
Our study highlights an emerging, broad role for ANC-1 in neuronal development, and unveils a new and unexpected mechanism by which RPM-1 functions.
Title: The Nesprin family member ANC-1 regulates synapse formation and axon termination by functioning in a pathway with RPM-1 and β-Catenin.
Genetic, transgenic, and biochemical studies indicated that PPM-2 functions coordinately with the ubiquitin ligase activity of RPM-1 and the F-box protein FSN-1 to negatively regulate DLK-1
Title: RPM-1 uses both ubiquitin ligase and phosphatase-based mechanisms to regulate DLK-1 during neuronal development.
The findings show that axon termination defects are a core phenotype caused by loss of function in rpm-1.
Title: RPM-1 is localized to distinct subcellular compartments and regulates axon length in GABAergic motor neurons.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C01B7.6 (e-PCR)
- UniSTS:312146

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase kinase kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of 3'-UTR-mediated mRNA stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of axon extension involved in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of axon extension involved in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of axon extension involved in regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of p38MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of sensory neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of sensory neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of presynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of 3'-UTR-mediated mRNA stabilization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of axon extension involved in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of dorsal/ventral axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of motor neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of presynapse assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of protein stability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of sensory neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of synapse organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic assembly at neuromuscular junction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic assembly at neuromuscular junction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in presynaptic periactive zone	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase rpm-1

NP_505267.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

8805399..8819955 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_072866.4 → NP_505267.1 E3 ubiquitin-protein ligase rpm-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_505267.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17551

Conserved Domains (6) summary

smart00336
Location:3331 → 3379

BBOX; B-Box-type zinc finger

pfam00415
Location:787 → 833

RCC1; Regulator of chromosome condensation (RCC1) repeat

pfam08005
Location:1057 → 1203

PHR; PHR domain

pfam13540
Location:769 → 798

RCC1_2; Regulator of chromosome condensation (RCC1) repeat

pfam13639
Location:3515 → 3567

zf-RING_2; Ring finger domain

cl02148
Location:2891 → 3049

APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination