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    F22G12.5 DOCKER domain-containing protein;PH domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173181, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F22G12.5
    Official Full Name
    DOCKER domain-containing protein;PH domain-containing protein
    Primary source
    WormBase:WBGene00009065
    Locus tag
    CELE_F22G12.5
    See related
    AllianceGenome:WB:WBGene00009065
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Rho protein signal transduction. Is expressed in intestine; nervous system; spermatheca; and uterine toroidal epithelial cell. Orthologous to several human genes including DOCK11 (dedicator of cytokinesis 11). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F22G12.5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    29
    Sequence:
    Chromosome: I; NC_003279.8 (13162492..13182726)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ANK_REP_REGION domain-containing protein;FYVE-type domain-containing protein Neighboring gene tRNA-Val Neighboring gene ncRNA Neighboring gene tRNA-Val Neighboring gene Defensin-like protein Neighboring gene protein-disulfide reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DOCKER domain-containing protein;PH domain-containing protein
    NP_001252088.2
    • Confirmed by transcript evidence
    NP_001252089.1
    • Confirmed by transcript evidence
    NP_001300393.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13162492..13182726
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001265159.4 → NP_001252088.2  PH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001252088.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBE8
      Conserved Domains (4) summary
      pfam06920
      Location:1803 → 2301
      DHR-2; Dock homology region 2
      pfam11878
      Location:79 → 189
      DUF3398; Domain of unknown function (DUF3398)
      cl14603
      Location:758 → 945
      C2; C2 domain
      cl17171
      Location:208 → 326
      PH-like; Pleckstrin homology-like domain

    2. NM_001313464.2 → NP_001300393.1  PH domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AR51
      Conserved Domains (4) summary
      pfam06920
      Location:1805 → 2303
      DHR-2; Dock homology region 2
      pfam11878
      Location:79 → 189
      DUF3398; Domain of unknown function (DUF3398)
      cl14603
      Location:760 → 947
      C2; C2 domain
      cl17171
      Location:208 → 326
      PH-like; Pleckstrin homology-like domain

    3. NM_001265160.3 → NP_001252089.1  DOCKER domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001252089.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G1K0Y1
      Conserved Domains (1) summary
      pfam06920
      Location:734 → 1232
      DHR-2; Dock homology region 2
    Nucleotide Protein
    Heading Accession and Version

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