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    eif-3.H Eukaryotic translation initiation factor 3 subunit H [ Caenorhabditis elegans ]

    Gene ID: 172044, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eif-3.H
    Official Full Name
    Eukaryotic translation initiation factor 3 subunit H
    Primary source
    WormBase:WBGene00001231
    Locus tag
    CELE_C41D11.2
    See related
    AllianceGenome:WB:WBGene00001231
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metallopeptidase activity. Predicted to contribute to translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic 43S preinitiation complex and eukaryotic translation initiation factor 3 complex. Is expressed in several structures, including enteric muscle; excretory cell; intestine; nervous system; and vulval muscle. Human ortholog(s) of this gene implicated in breast cancer; prostate cancer; and prostate carcinoma. Orthologous to human EIF3H (eukaryotic translation initiation factor 3 subunit H). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See eif-3.H in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (4444719..4446613)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Cysteine/serine-rich nuclear protein N-terminal domain-containing protein Neighboring gene Endonuclease G, mitochondrial Neighboring gene TM2 domain-containing protein C41D11.9 Neighboring gene Protein cmt-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genetic screen identifies C. elegans eif-3.H and hrpr-1 as pro-apoptotic genes and potential activators of egl-1 expression. Jiang Y, et al. MicroPubl Biol, 2024. PMID 38434221, Free PMC Article
    2. Axon guidance genes identified in a large-scale RNAi screen using the RNAi-hypersensitive Caenorhabditis elegans strain nre-1(hd20) lin-15b(hd126). Schmitz C, et al. Proc Natl Acad Sci U S A, 2007 Jan 16. PMID 17213328, Free PMC Article
    3. Mechanism and regulation of translation in C. elegans. Rhoads RE, et al. WormBook, 2006 Jan 28. PMID 18050488, Free PMC Article
    4. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article
    5. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metallopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in formation of cytoplasmic translation initiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 43S preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic 43S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Eukaryotic translation initiation factor 3 subunit H
    NP_491370.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4444719..4446613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058969.5 → NP_491370.1  Eukaryotic translation initiation factor 3 subunit H [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491370.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01974
      Conserved Domains (1) summary
      cd08065
      Location:13 → 296
      MPN_eIF3h; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF2h
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O01974.2

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