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    fars-2 FDX-ACB domain-containing protein;phenylalanine--tRNA ligase [ Caenorhabditis elegans ]

    Gene ID: 180303, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fars-2
    Official Full Name
    FDX-ACB domain-containing protein;phenylalanine--tRNA ligase
    Primary source
    WormBase:WBGene00013361
    Locus tag
    CELE_Y60A3A.13
    See related
    AllianceGenome:WB:WBGene00013361
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phenylalanine-tRNA ligase activity. Predicted to be involved in phenylalanyl-tRNA aminoacylation. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 14 and hereditary spastic paraplegia 77. Orthologous to human FARS2 (phenylalanyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fars-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (19897977..19907434, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene SCP domain-containing protein Neighboring gene Polypeptide N-acetylgalactosaminyltransferase 4;polypeptide N-acetylgalactosaminyltransferase Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene Serine/threonine-protein kinase chk-2 Neighboring gene Protein YIPF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article
    2. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phenylalanine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phenylalanine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phenylalanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phenylalanyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FDX-ACB domain-containing protein;phenylalanine--tRNA ligase
    NP_001123055.1
    • Confirmed by transcript evidence
    NP_001367255.1
    • Confirmed by transcript evidence
    NP_507852.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      19897977..19907434 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075451.6 → NP_507852.2  phenylalanine--tRNA ligase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507852.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECI8
      Conserved Domains (1) summary
      PLN02788
      Location:22 → 458
      PLN02788; phenylalanine-tRNA synthetase

    2. NM_001380876.1 → NP_001367255.1  phenylalanine--tRNA ligase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEN1
      Conserved Domains (1) summary
      PLN02788
      Location:2 → 428
      PLN02788; phenylalanine-tRNA synthetase

    3. NM_001129583.4 → NP_001123055.1  FDX-ACB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001123055.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B1V8K6
      Conserved Domains (1) summary
      smart00896
      Location:3 → 74
      FDX-ACB; Ferredoxin-fold anticodon binding domain
    Nucleotide Protein
    Heading Accession and Version

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