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    F46F11.1 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase [ Caenorhabditis elegans ]

    Gene ID: 172221, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F46F11.1
    Official Full Name
    Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
    Primary source
    WormBase:WBGene00018508
    Locus tag
    CELE_F46F11.1
    See related
    AllianceGenome:WB:WBGene00018508
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity and inositol phosphate kinase activity. Predicted to be involved in inositol metabolic process and inositol phosphate biosynthetic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 100. Orthologous to several human genes including PPIP5K2 (diphosphoinositol pentakisphosphate kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F46F11.1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    24
    Sequence:
    Chromosome: I; NC_003279.8 (5627813..5637621)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Tenascin Neighboring gene RNA (guanine-9-)-methyltransferase domain-containing protein 1 Neighboring gene C2H2-type domain-containing protein Neighboring gene Protein-tyrosine phosphatase catalytic domain-containing protein Neighboring gene Col_cuticle_N domain-containing protein Neighboring gene ATP-dependent RNA helicase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. β-Integrin de-phosphorylation by the Density-Enhanced Phosphatase DEP-1 attenuates EGFR signaling in C. elegans. Walser M, et al. PLoS Genet, 2017 Jan. PMID 28135265, Free PMC Article
    2. Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states. Tan D, et al. Elife, 2016 Mar 8. PMID 26952210, Free PMC Article
    3. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
    4. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    5. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 5-diphosphoinositol pentakisphosphate 1-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5-diphosphoinositol pentakisphosphate 1-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 5-diphosphoinositol pentakisphosphate 1-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables diphosphoinositol pentakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diphosphoinositol pentakisphosphate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol hexakisphosphate 1-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol hexakisphosphate 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol hexakisphosphate 5-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol hexakisphosphate 5-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables inositol hexakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol hexakisphosphate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol-1,3,4,5,6-pentakisphosphate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol-1,3,4,5,6-pentakisphosphate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in inositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inositol metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in inositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
    NP_740855.2
    • Confirmed by transcript evidence
    NP_740856.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5627813..5637621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171837.9 → NP_740856.1  Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740856.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91309
      Conserved Domains (2) summary
      pfam00328
      Location:363 → 914
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      cl17255
      Location:208 → 309
      ATP-grasp_4; ATP-grasp domain

    2. NM_170868.6 → NP_740855.2  Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740855.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91309, Q8T3B4
      Conserved Domains (3) summary
      COG0189
      Location:207 → 299
      RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
      pfam00328
      Location:363 → 914
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:17 → 108
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P91309.3

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