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    abcf-3 ABC transporter domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175873, updated on 9-Dec-2024

    Summary

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    Official Symbol
    abcf-3
    Official Full Name
    ABC transporter domain-containing protein
    Primary source
    WormBase:WBGene00018339
    Locus tag
    CELE_F42A10.1
    See related
    AllianceGenome:WB:WBGene00018339
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity. Involved in positive regulation of peptidyl-serine phosphorylation; regulation of apoptotic process; and regulation of translation. Predicted to be located in cytosolic ribosome. Is expressed in several structures, including body wall musculature; head neurons; hermaphrodite gonad; intestinal cell; and pharyngeal neurons. Orthologous to human ABCF3 (ATP binding cassette subfamily F member 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See abcf-3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (6173403..6176171)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Gamma-glutamylcyclotransferase family protein Neighboring gene Eukaryotic elongation factor 2 kinase Neighboring gene Protein CDV3 homolog Neighboring gene ncRNA Neighboring gene MD-2-related lipid-recognition domain-containing protein Neighboring gene MD-2-related lipid-recognition domain-containing protein Neighboring gene Zinc metalloproteinase nas-28

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The diversity of ABC transporter genes across the Phylum Nematoda. Langeland A, et al. Parasitol Int, 2021 Aug. PMID 33901678
    2. The translational regulators GCN-1 and ABCF-3 act together to promote apoptosis in C. elegans. Hirose T, et al. PLoS Genet, 2014 Aug. PMID 25101958, Free PMC Article
    3. The C. elegans glycopeptide hormone receptor ortholog, FSHR-1, regulates germline differentiation and survival. Cho S, et al. Curr Biol, 2007 Feb 6. PMID 17276913
    4. Using RNA interference to identify specific modifiers of a temperature-sensitive, embryonic-lethal mutation in the Caenorhabditis elegans ubiquitin-like Nedd8 protein modification pathway E1-activating gene rfl-1. Dorfman M, et al. Genetics, 2009 Aug. PMID 19528325, Free PMC Article
    5. β-Integrin de-phosphorylation by the Density-Enhanced Phosphatase DEP-1 attenuates EGFR signaling in C. elegans. Walser M, et al. PLoS Genet, 2017 Jan. PMID 28135265, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosolic ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ABC transporter domain-containing protein
    NP_498339.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6173403..6176171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065938.8 → NP_498339.1  ABC transporter domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498339.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20306
      Conserved Domains (3) summary
      cd03221
      Location:179 → 406
      ABCF_EF-3; ATP-binding cassette domain of elongation factor 3, subfamily F
      PLN03073
      Location:22 → 702
      PLN03073; ABC transporter F family; Provisional
      pfam12848
      Location:400 → 483
      ABC_tran_Xtn; ABC transporter
    Nucleotide Protein
    Heading Accession and Version

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