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    bra-2 MYND-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175255, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bra-2
    Official Full Name
    MYND-type domain-containing protein
    Primary source
    WormBase:WBGene00017757
    Locus tag
    CELE_F23H11.1
    See related
    AllianceGenome:WB:WBGene00017757
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metal ion binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription elongation by RNA polymerase II. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 30. Orthologous to human ZMYND11 (zinc finger MYND-type containing 11). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See bra-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (911261..912243)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene putative cardiolipin synthase (CMP-forming) Neighboring gene Deltamethrin resistance protein prag01 domain-containing protein Neighboring gene DUF148 domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The conserved Mynd domain of BS69 binds cellular and oncoviral proteins through a common PXLXP motif. Ansieau S, et al. J Biol Chem, 2002 Feb 15. PMID 11733528
    2. BIP, a BRAM-interacting protein involved in TGF-beta signalling, regulates body length in Caenorhabditis elegans. Sugawara K, et al. Genes Cells, 2001 Jul. PMID 11473578
    3. Alterations in Caenorhabditis elegans and Cronobacter sakazakii lipopolysaccharide during interaction. Sivamaruthi BS, et al. Arch Microbiol, 2015 Mar. PMID 25416126
    4. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article
    5. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MYND-type domain-containing protein
    NP_497292.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      911261..912243
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064891.4 → NP_497292.1  MYND-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497292.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01918
      Conserved Domains (1) summary
      pfam01753
      Location:151 → 185
      zf-MYND; MYND finger
    Nucleotide Protein
    Heading Accession and Version

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