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    lpd-5 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 172037, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lpd-5
    Official Full Name
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
    Primary source
    WormBase:WBGene00003061
    Locus tag
    CELE_ZK973.10
    See related
    AllianceGenome:WB:WBGene00003061
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in lipid storage. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Used to study mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in Leigh disease and nuclear type mitochondrial complex I deficiency 1. Orthologous to human NDUFS4 (NADH:ubiquinone oxidoreductase subunit S4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lpd-5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (4372255..4373018, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene BTB domain-containing protein Neighboring gene PPM-type phosphatase domain-containing protein Neighboring gene SS18 N-terminal domain-containing protein Neighboring gene Chromo domain-containing protein Neighboring gene Thioredoxin domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C elegans: a model for exploring the genetics of fat storage. McKay RM, et al. Dev Cell, 2003 Jan. PMID 12530969, Free PMC Article
    2. Neuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in C. elegans. Maglioni S, et al. Nat Commun, 2022 May 12. PMID 35551180, Free PMC Article
    3. The role of mitochondria in the life of the nematode, Caenorhabditis elegans. Tsang WY, et al. Biochim Biophys Acta, 2003 Jul 14. PMID 12853115
    4. Longevity determined by developmental arrest genes in Caenorhabditis elegans. Chen D, et al. Aging Cell, 2007 Aug. PMID 17521386, Free PMC Article
    5. Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans. Brock TJ, et al. Genetics, 2007 Jun. PMID 17435249, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in electron transport chain IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial electron transport, NADH to ubiquinone IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
    NP_001370829.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4372255..4373018 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001382913.2 → NP_001370829.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N4L8
      Conserved Domains (1) summary
      pfam04800
      Location:75 → 171
      ETC_C1_NDUFA4; ETC complex I subunit conserved region
    Nucleotide Protein
    Heading Accession and Version

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