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    sup-18 Iodotyrosine dehalogenase 1 homolog [ Caenorhabditis elegans ]

    Gene ID: 182108, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sup-18
    Official Full Name
    Iodotyrosine dehalogenase 1 homolog
    Primary source
    WormBase:WBGene00015334
    Locus tag
    CELE_C02C2.5
    See related
    AllianceGenome:WB:WBGene00015334
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable oxidoreductase activity. Predicted to be involved in tyrosine metabolic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in anal depressor muscle; body wall musculature; head neurons; and vulval muscle. Human ortholog(s) of this gene implicated in thyroid dyshormonogenesis 4. Orthologous to human IYD (iodotyrosine deiodinase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sup-18 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (7877176..7878902, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene putative transporter slc-17.3 Neighboring gene Acetylcholine receptor-like protein cup-4 Neighboring gene Putative tyrosinase-like protein tyr-1 Neighboring gene TIP41-like protein Neighboring gene Transmembrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans iodotyrosine deiodinase ortholog SUP-18 functions through a conserved channel SC-box to regulate the muscle two-pore domain potassium channel SUP-9. de la Cruz IP, et al. PLoS Genet, 2014 Feb. PMID 24586202, Free PMC Article
    2. sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans. de la Cruz IP, et al. J Neurosci, 2003 Oct 8. PMID 14534247, Free PMC Article
    3. A visible allele of the muscle gene sup-10X of C. elegans. Greenwald I, et al. Genetics, 1986 May. PMID 3710144, Free PMC Article
    4. The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction. Levin JZ, et al. J Cell Biol, 1992 Apr. PMID 1313436, Free PMC Article
    5. Three new classes of mutations in the Caenorhabditis elegans muscle gene sup-9. Levin JZ, et al. Genetics, 1993 Sep. PMID 8224828, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables iodotyrosine deiodinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tyrosine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Iodotyrosine dehalogenase 1 homolog
    NP_498712.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7877176..7878902 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066311.6 → NP_498712.3  Iodotyrosine dehalogenase 1 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498712.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      L7TUZ3, P34273
      Conserved Domains (2) summary
      cd02144
      Location:128 → 321
      iodotyrosine_dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers.
      cl00263
      Location:15 → 47
      TFold; Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34273.3

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