U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    parp-1 Poly [ADP-ribose] polymerase;Poly [ADP-ribose] polymerase 1 [ Caenorhabditis elegans ]

    Gene ID: 266823, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    parp-1
    Official Full Name
    Poly [ADP-ribose] polymerase;Poly [ADP-ribose] polymerase 1
    Primary source
    WormBase:WBGene00004049
    Locus tag
    CELE_Y71F9AL.18
    See related
    AllianceGenome:WB:WBGene00004049
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables NAD+-protein poly-ADP-ribosyltransferase activity. Involved in determination of adult lifespan. Predicted to be located in nucleus. Predicted to be active in nucleolus. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including arthritis; asthma; bacterial meningitis; neurodegenerative disease (multiple); and stomach carcinoma. Orthologous to human PARP1 (poly(ADP-ribose) polymerase 1). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See parp-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (2907730..2924713, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Coatomer subunit alpha Neighboring gene maleylacetoacetate isomerase Neighboring gene Tyrosine-protein phosphatase Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA (guanine(10)-N2)-methyltransferase homolog Neighboring gene Translocon-associated protein subunit alpha

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Elemental bioimaging of Cisplatin in Caenorhabditis elegans by LA-ICP-MS. Crone B, et al. Metallomics, 2015 Jul. PMID 25996669, Free PMC Article
    2. Melatonin derivative 6a as a PARP-1 inhibitor for the treatment of Parkinson's disease. Ma QW, et al. Front Pharmacol, 2024. PMID 38476326, Free PMC Article
    3. The Lifespan Extension Ability of Nicotinic Acid Depends on Whether the Intracellular NAD(+) Level Is Lower than the Sirtuin-Saturating Concentrations. Yang NC, et al. Int J Mol Sci, 2019 Dec 24. PMID 31878234, Free PMC Article
    4. Ionizing radiations in Caenorhabditis elegans induce poly(ADP-ribosyl)ation, a conserved DNA-damage response essential for survival. Dequen F, et al. DNA Repair (Amst), 2005 Jul 12. PMID 15923155
    5. PARP-1 Inhibition Rescues Short Lifespan in Hyperglycemic C. Elegans And Improves GLP-1 Secretion in Human Cells. Xia Q, et al. Aging Dis, 2018 Feb. PMID 29392078, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of PME-1 decreases embryonic survival rate of irradiated worms.
      Title: Ionizing radiations in Caenorhabditis elegans induce poly(ADP-ribosyl)ation, a conserved DNA-damage response essential for survival.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+-protein ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+-protein poly-ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NAD+-protein poly-ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+-protein poly-ADP-ribosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Poly [ADP-ribose] polymerase;Poly [ADP-ribose] polymerase 1
    NP_001300471.1
    • Confirmed by transcript evidence
    NP_001300472.1
    • Confirmed by transcript evidence
    NP_001300473.1
    • Confirmed by transcript evidence
    NP_491072.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2907730..2924713 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058671.11 → NP_491072.1  Poly [ADP-ribose] polymerase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491072.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MZU4, Q9N4H4
      Conserved Domains (6) summary
      cd08001
      Location:465 → 570
      WGR_PARP1_like; WGR domain of poly(ADP-ribose) polymerase 1 and similar proteins
      PLN03123
      Location:5 → 943
      PLN03123; poly [ADP-ribose] polymerase; Provisional
      cd01437
      Location:586 → 938
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      pfam00645
      Location:13 → 90
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam08063
      Location:314 → 368
      PADR1; PADR1 (NUC008) domain
      cl02166
      Location:236 → 272
      RRS1; Ribosome biogenesis regulatory protein (RRS1)

    2. NM_001313544.3 → NP_001300473.1  Poly [ADP-ribose] polymerase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARD5
      Conserved Domains (2) summary
      cd01437
      Location:3 → 341
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      pfam00644
      Location:129 → 341
      PARP; Poly(ADP-ribose) polymerase catalytic domain

    3. NM_001313543.3 → NP_001300472.1  Poly [ADP-ribose] polymerase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AWQ2
      Conserved Domains (2) summary
      cd01437
      Location:1 → 250
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      pfam00644
      Location:38 → 250
      PARP; Poly(ADP-ribose) polymerase catalytic domain

    4. NM_001313542.3 → NP_001300471.1  Poly [ADP-ribose] polymerase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUD3
      Conserved Domains (1) summary
      cl00283
      Location:11 → 81
      ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N4H4.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.