sesn-1 Sestrin homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sesn-1
Official Full Name: Sestrin homolog
Primary source: WormBase:WBGene00022279
Locus tag: CELE_Y74C9A.5
See related: AllianceGenome:WB:WBGene00022279
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable L-leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Predicted to be involved in several processes, including cellular response to L-leucine; cellular response to leucine starvation; and negative regulation of TORC1 signaling. Predicted to be located in cytoplasm and nucleus. Orthologous to several human genes including SESN1 (sestrin 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sesn-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 5

Sequence:: Chromosome: I; NC_003279.8 (27591..32548, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results suggest that SESN-1 is required for normal lifespan in Caenorhabditis elegans and its function in muscle cells prevents muscle degeneration over a lifetime.
Title: SESN-1 is a positive regulator of lifespan in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables L-leucine binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on peroxide as acceptor	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to L-leucine	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to leucine starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TORC1 signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macroautophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of response to reactive oxygen species	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Sestrin homolog

NP_490664.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

27591..32548 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058263.5 → NP_490664.2 Sestrin homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_490664.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9N4D6

Conserved Domains (1) summary

cl00460
Location:32 → 460

CMD; Carboxymuconolactone decarboxylase family