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    arg-1 Delta-like protein [ Caenorhabditis elegans ]

    Gene ID: 180501, updated on 9-Dec-2024

    Summary

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    Official Symbol
    arg-1
    Official Full Name
    Delta-like protein
    Primary source
    WormBase:WBGene00000185
    Locus tag
    CELE_F31A9.3
    See related
    AllianceGenome:WB:WBGene00000185
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable Notch binding activity. Predicted to be involved in cell communication. Predicted to be located in membrane. Is expressed in several structures, including head mesodermal cell; male distal tip cell; non-striated muscle; somatic gonad precursor; and tail. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See arg-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Sequence:
    Chromosome: X; NC_003284.9 (1786907..1788405)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Elongin-C Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Twist-Box domain of the C. elegans Twist homolog, HLH-8, plays a complex role in transcriptional regulation. Gruss MJ, et al. Genetics, 2023 Aug 9. PMID 37067863, Free PMC Article
    2. The C. elegans Twist target gene, arg-1, is regulated by distinct E box promoter elements. Zhao J, et al. Mech Dev, 2007 May. PMID 17369030, Free PMC Article
    3. Interchangeability of Caenorhabditis elegans DSL proteins and intrinsic signalling activity of their extracellular domains in vivo. Fitzgerald K, et al. Development, 1995 Dec. PMID 8575327
    4. A "latent niche" mechanism for tumor initiation. McGovern M, et al. Proc Natl Acad Sci U S A, 2009 Jul 14. PMID 19564624, Free PMC Article
    5. Identification of novel target genes of CeTwist and CeE/DA. Wang P, et al. Dev Biol, 2006 May 15. PMID 16480708

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables Notch binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell communication IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Delta-like protein
    NP_001024615.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      1786907..1788405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029444.1 → NP_001024615.1  Delta-like protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024615.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYS0, Q17377
      Conserved Domains (2) summary
      smart00051
      Location:107 → 171
      DSL; delta serrate ligand
      cd00054
      Location:174 → 208
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    Nucleotide Protein
    Heading Accession and Version

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