pat-6 Paralyzed arrest at two-fold protein 6 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pat-6
Official Full Name: Paralyzed arrest at two-fold protein 6
Primary source: WormBase:WBGene00003932
Locus tag: CELE_T21D12.4
See related: AllianceGenome:WB:WBGene00003932
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable actin binding activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of sarcomere organization; and striated muscle cell development. Located in M band; basal plasma membrane; and striated muscle dense body. Is expressed in body wall musculature; gonad; non-striated muscle; and touch receptor neurons. Orthologous to several human genes including PARVA (parvin alpha). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pat-6 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (261886..264232, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PAT-6/actopaxin plays essential roles during the maturation of integrin-mediated muscle attachments in vivo.
Title: C. elegans PAT-6/actopaxin plays a critical role in the assembly of integrin adhesion complexes in vivo.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T21D12.4 (e-PCR)
- UniSTS:315044

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell projection assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of cell polarity regulating cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in striated muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in substrate adhesion-dependent cell spreading	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in M band	IDA Inferred from Direct Assay more info	PubMed
located_in M band	IEA Inferred from Electronic Annotation more info
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in striated muscle dense body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Paralyzed arrest at two-fold protein 6

NP_499891.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

261886..264232 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067490.6 → NP_499891.1 Paralyzed arrest at two-fold protein 6 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499891.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O16785

Conserved Domains (1) summary

pfam00307
Location:103 → 201

CH; Calponin homology (CH) domain