tni-1 Troponin I 1 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: tni-1
Official Full Name: Troponin I 1
Primary source: WormBase:WBGene00006584
Locus tag: CELE_F42E11.4
See related: AllianceGenome:WB:WBGene00006584
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables troponin C binding activity. Involved in backward locomotion. Part of muscle thin filament tropomyosin. Is expressed in several structures, including body wall musculature; gonad; non-striated muscle; rectal muscle; and in male. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita; distal arthrogryposis type 2B1; and intrinsic cardiomyopathy (multiple). Orthologous to human TNNI1 (troponin I1, slow skeletal type); TNNI2 (troponin I2, fast skeletal type); and TNNI3 (troponin I3, cardiac type). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Troponin I regulates contraction of non-striated actomyosin networks and is an essential cytoskeletal component of the C. elegans reproductive system.
Title: Troponin I controls ovulatory contraction of non-striated actomyosin networks in the C. elegans somatic gonad.
evolved following duplication of the pharynx gene troponin-4
Title: Tissue expression of four troponin I genes and their molecular interactions with two troponin C isoforms in Caenorhabditis elegans.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables troponin C binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in backward locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle contraction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of muscle thin filament tropomyosin	IDA Inferred from Direct Assay more info	PubMed
part_of troponin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of troponin complex	IEA Inferred from Electronic Annotation more info