Tlnrd1 talin rod domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tlnrd1provided by MGI
Official Full Name: talin rod domain containing 1provided by MGI
Primary source: MGI:MGI:1891420
See related: Ensembl:ENSMUSG00000070462 AllianceGenome:MGI:1891420
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mesdc1
Summary: Enables actin binding activity. Colocalizes with stress fiber. Is expressed in several structures, including 4-cell stage embryo; genitourinary system; liver; lung; and spleen. Orthologous to human TLNRD1 (talin rod domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 7 D3; 7 48.33 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (83529703..83533549, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (83880495..83884341, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study show that the MESDc1 protein, which is predicted to have a similar fold, is a novel actin-binding protein.
Title: Central region of talin has a unique fold that binds vinculin and actin.

Submit: New GeneRIF Correction

General gene information

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Markers

RH131605 (e-PCR)
- UniSTS:214888

AW061151 (e-PCR)
- UniSTS:179604

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
colocalizes_with stress fiber	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: talin rod domain-containing protein 1

Names: mesoderm development candidate 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.