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    cpd-1 Carboxypeptidase D [ Caenorhabditis elegans ]

    Gene ID: 172206, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cpd-1
    Official Full Name
    Carboxypeptidase D
    Primary source
    WormBase:WBGene00019074
    Locus tag
    CELE_F59A3.1
    See related
    AllianceGenome:WB:WBGene00019074
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in peptide metabolic process and protein processing. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in pharynx. Orthologous to human CPD (carboxypeptidase D). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cpd-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    21
    Sequence:
    Chromosome: I; NC_003279.8 (5520389..5529763)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene Transmembrane protein Neighboring gene ncRNA Neighboring gene Tyrosine-protein kinase Neighboring gene PAP-associated domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    2. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Carboxypeptidase D
    NP_491619.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5520389..5529763
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059218.8 → NP_491619.2  Carboxypeptidase D [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491619.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91359
      Conserved Domains (2) summary
      cd03858
      Location:79 → 373
      M14_CP_N-E_like; Peptidase M14 carboxypeptidase subfamily N/E-like
      cd11308
      Location:377 → 451
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    Nucleotide Protein
    Heading Accession and Version

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