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    glr-7 GLutamate Receptor family (AMPA) [ Caenorhabditis elegans ]

    Gene ID: 180547, updated on 9-Dec-2024

    Summary

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    Official Symbol
    glr-7
    Official Full Name
    GLutamate Receptor family (AMPA)
    Primary source
    WormBase:WBGene00001618
    Locus tag
    CELE_C43H6.9
    See related
    AllianceGenome:WB:WBGene00001618
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to be located in membrane. Predicted to be active in postsynaptic density membrane. Is expressed in pharyngeal neurons. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 18. Orthologous to human GRID1 (glutamate ionotropic receptor delta type subunit 1) and GRID2 (glutamate ionotropic receptor delta type subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See glr-7 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    16
    Sequence:
    Chromosome: X; NC_003284.9 (2413909..2419877, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene TRansport Protein Particle Neighboring gene Helix-loop-helix protein 15 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Soluble guanylate cyclase gcy-31;guanylate cyclase Neighboring gene ncRNA Neighboring gene RING-Gid-type domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of Caenorhabditis elegans glutamate receptor subunits by domain transplantation. Strutz-Seebohm N, et al. J Biol Chem, 2003 Nov 7. PMID 12930835
    2. Ionotropic glutamate receptors in Caenorhabditis elegans. Brockie PJ, et al. Neurosignals, 2003 May-Jun. PMID 12904685
    3. Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding. Greer ER, et al. Cell Metab, 2008 Aug. PMID 18680713, Free PMC Article
    4. Ionotropic glutamate receptors: genetics, behavior and electrophysiology. Brockie PJ, et al. WormBook, 2006 Jan 19. PMID 18050468, Free PMC Article
    5. Temperature regulates synaptic subcellular specificity mediated by inhibitory glutamate signaling. Wang M, et al. PLoS Genet, 2021 Jan. PMID 33428618, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GLutamate Receptor family (AMPA)
    NP_001337310.1
    • Product from WormBase gene class glr;
      Partially confirmed by transcript evidence
    NP_001359931.1
    • Product from WormBase gene class glr;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      2413909..2419877 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373243.1 → NP_001359931.1  GLutamate Receptor family (AMPA) [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18591
      Conserved Domains (1) summary
      cd13717
      Location:159 → 553
      PBP2_iGluR_putative; The ligand-binding domain of putative ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

    2. NM_001350348.3 → NP_001337310.1  GLutamate Receptor family (AMPA) [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1T5HUM0
      Conserved Domains (2) summary
      cd13717
      Location:373 → 767
      PBP2_iGluR_putative; The ligand-binding domain of putative ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cl10011
      Location:102 → 220
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    Nucleotide Protein
    Heading Accession and Version

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