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    lite-1 High-energy light unresponsive protein 1 [ Caenorhabditis elegans ]

    Gene ID: 180894, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lite-1
    Official Full Name
    High-energy light unresponsive protein 1
    Primary source
    WormBase:WBGene00001803
    Locus tag
    CELE_C14F11.3
    See related
    AllianceGenome:WB:WBGene00001803
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables blue light photoreceptor activity. Involved in several processes, including negative phototaxis; phototransduction; and response to UV-A. Located in neuron projection; neuronal cell body; and plasma membrane. Is expressed in ganglia; hyp3; and pharyngeal neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lite-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    11
    Sequence:
    Chromosome: X; NC_003284.9 (6226126..6230769, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene AIP3 domain-containing protein Neighboring gene SHSP domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reactive oxygen species drive foraging decisions in Caenorhabditis elegans. Bischer AP, et al. Redox Biol, 2023 Nov. PMID 37864874, Free PMC Article
    2. Photoactivated adenylyl cyclases as optogenetic modulators of neuronal activity. Costa WS, et al. Methods Mol Biol, 2014. PMID 24718801
    3. LITE-1 mediates behavioral responses to X-rays in Caenorhabditis elegans. Cannon KE, et al. Front Neurosci, 2023. PMID 37638310, Free PMC Article
    4. The C. elegans Taste Receptor Homolog LITE-1 Is a Photoreceptor. Gong J, et al. Cell, 2016 Nov 17. PMID 27863243, Free PMC Article
    5. Regulation of photosensation by hydrogen peroxide and antioxidants in C. elegans. Zhang W, et al. PLoS Genet, 2020 Dec. PMID 33301443, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure-function analysis suggests that the photoreceptor LITE-1 is a light-activated ion channel.
      Title: Structure-function analysis suggests that the photoreceptor LITE-1 is a light-activated ion channel.
    2. Regulation of photosensation by hydrogen peroxide and antioxidants in C. elegans.
      Title: Regulation of photosensation by hydrogen peroxide and antioxidants in C. elegans.
    3. Unlike typical photoreceptors employing a prosthetic chromophore to capture photons, LITE-1 strictly depends on its protein conformation for photon absorption; further two tryptophan residues critical for LITE-1 function were identified. Interestingly, unlike GPCRs, LITE-1 adopts a reversed membrane topology. Thus, LITE-1, a taste receptor homolog, represents a distinct type of photoreceptor in the animal kingdom.
      Title: The C. elegans Taste Receptor Homolog LITE-1 Is a Photoreceptor.
    4. receptor family members LITE-1 and GUR-3 are required for the inhibition of feeding by light and hydrogen peroxide.
      Title: Light and hydrogen peroxide inhibit C. elegans Feeding through gustatory receptor orthologs and pharyngeal neurons.
    5. data suggest a model in which LITE-1 transduces light signals in a photoreceptor neuron via G protein signaling, leading to upregulation of the second messenger cGMP, followed by opening of cGMP-sensitive CNG channels and stimulation of photoreceptors
      Title: C. elegans phototransduction requires a G protein-dependent cGMP pathway and a taste receptor homolog.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables blue light photoreceptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables blue light photoreceptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables photoreceptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in blue light signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of sweet taste IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative phototaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phototransduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to UV IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to UV-A IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to UV-A IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to blue light IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of taste IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    High-energy light unresponsive protein 1
    NP_509043.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      6226126..6230769 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076642.7 → NP_509043.3  High-energy light unresponsive protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509043.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17990, Q963E8
      Conserved Domains (1) summary
      pfam08395
      Location:75 → 425
      7tm_7; 7tm Chemosensory receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q17990.3

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