gst-23 Glutathione S-transferase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gst-23
Official Full Name: Glutathione S-transferase
Primary source: WormBase:WBGene00001771
Locus tag: CELE_T28A11.11
See related: AllianceGenome:WB:WBGene00001771
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); eye disease (multiple); hematopoietic system disease (multiple); and respiratory system disease (multiple). Orthologous to several human genes including GSTP1 (glutathione S-transferase pi 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gst-23 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 3

Sequence:: Chromosome: V; NC_003283.11 (3243284..3244502)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T28A11.12 (e-PCR)
- UniSTS:311047

T28A11.11 (e-PCR)
- UniSTS:318555

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Glutathione S-transferase

NP_503889.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

3243284..3244502

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_071488.4 → NP_503889.1 Glutathione S-transferase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_503889.1

Status: REVIEWED

UniProtKB/TrEMBL

P91505

Conserved Domains (3) summary

PTZ00057
Location:5 → 197

PTZ00057; glutathione s-transferase; Provisional

cd03076
Location:2 → 73

GST_N_Pi; GST_N family, Class Pi subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

cl02776
Location:81 → 208

GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family