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    pde-3 Phosphodiesterase;putative 3',5'-cyclic phosphodiesterase pde-3 [ Caenorhabditis elegans ]

    Gene ID: 183981, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pde-3
    Official Full Name
    Phosphodiesterase;putative 3',5'-cyclic phosphodiesterase pde-3
    Primary source
    WormBase:WBGene00008443
    Locus tag
    CELE_E01F3.1
    See related
    AllianceGenome:WB:WBGene00008443
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Involved in several processes, including determination of adult lifespan; negative regulation of cGMP-mediated signaling; and response to hydrogen peroxide. Is expressed in hypodermis; intestine; and nervous system. Human ortholog(s) of this gene implicated in hypertension and brachydactyly syndrome. Orthologous to human PDE3A (phosphodiesterase 3A) and PDE3B (phosphodiesterase 3B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pde-3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    16
    Sequence:
    Chromosome: II; NC_003280.10 (14919705..14953353)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Homeobox domain-containing protein Neighboring gene Cell wall protein DAN4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Elongation of very long chain fatty acids protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. cGMP dynamics that underlies thermosensation in temperature-sensing neuron regulates thermotaxis behavior in C. elegans. Aoki I, et al. PLoS One, 2022. PMID 36472979, Free PMC Article
    2. GCY-8, PDE-2, and NCS-1 are critical elements of the cGMP-dependent thermotransduction cascade in the AFD neurons responsible for C. elegans thermotaxis. Wang D, et al. J Gen Physiol, 2013 Oct. PMID 24081984, Free PMC Article
    3. The Receptor-Bound Guanylyl Cyclase DAF-11 Is the Mediator of Hydrogen Peroxide-Induced cGMP Increase in Caenorhabditis elegans [corrected]. Beckert U, et al. PLoS One, 2013. PMID 24015261, Free PMC Article
    4. Changes in cGMP levels affect the localization of EGL-4 in AWC in Caenorhabditis elegans. O'Halloran DM, et al. PLoS One, 2012. PMID 22319638, Free PMC Article
    5. Environmental alkalinity sensing mediated by the transmembrane guanylyl cyclase GCY-14 in C. elegans. Murayama T, et al. Curr Biol, 2013 Jun 3. PMID 23664973

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemosensory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chemotaxis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of cGMP-mediated signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phototransduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to alkaline pH IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to hydrogen peroxide IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Phosphodiesterase;putative 3',5'-cyclic phosphodiesterase pde-3
    NP_001254452.1
    • Partially confirmed by transcript evidence
    NP_001254454.1
    • Partially confirmed by transcript evidence
    NP_001293569.1
    • Confirmed by transcript evidence
    NP_001293570.1
    • Confirmed by transcript evidence
    NP_001293571.1
    • Partially confirmed by transcript evidence
    NP_001293572.1
    • Partially confirmed by transcript evidence
    NP_001367248.1
    • Confirmed by transcript evidence
    NP_001368261.1
    • Confirmed by transcript evidence
    NP_001370153.1
    • Confirmed by transcript evidence
    NP_497084.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      14919705..14953353
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383996.1 → NP_001370153.1  putative 3',5'-cyclic phosphodiesterase pde-3 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam00233
      Location:302 → 557
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    2. NM_001306642.3 → NP_001293571.1  Phosphodiesterase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293571.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PEM9
      Conserved Domains (1) summary
      pfam00233
      Location:355 → 610
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    3. NM_001381668.1 → NP_001367248.1  putative 3',5'-cyclic phosphodiesterase pde-3 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7FAS9, B7FAT0, G5EG24, Q8I0P7, Q9BH44
      Conserved Domains (1) summary
      pfam00233
      Location:355 → 610
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    4. NM_001306643.3 → NP_001293572.1  Phosphodiesterase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293572.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBF4
      Conserved Domains (1) summary
      pfam00233
      Location:302 → 557
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    5. NM_001306640.4 → NP_001293569.1  Phosphodiesterase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293569.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PM84
      Conserved Domains (1) summary
      pfam00233
      Location:255 → 510
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    6. NM_001381670.1 → NP_001368261.1  Phosphodiesterase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBS8
      Conserved Domains (1) summary
      pfam00233
      Location:255 → 510
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    7. NM_001267523.2 → NP_001254452.1  putative 3',5'-cyclic phosphodiesterase pde-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254452.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8I0P7
      Conserved Domains (1) summary
      pfam00233
      Location:251 → 506
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    8. NM_001306641.2 → NP_001293570.1  Phosphodiesterase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293570.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PRI1
      Conserved Domains (1) summary
      pfam00233
      Location:251 → 506
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    9. NM_064683.6 → NP_497084.2  putative 3',5'-cyclic phosphodiesterase pde-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497084.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8I0P7
      Conserved Domains (1) summary
      pfam00233
      Location:134 → 389
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    10. NM_001267525.3 → NP_001254454.1  putative 3',5'-cyclic phosphodiesterase pde-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254454.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8I0P7
      Conserved Domains (1) summary
      pfam00233
      Location:169 → 424
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8I0P7.4

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