U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ifd-2 Intermediate filament protein ifd-2 [ Caenorhabditis elegans ]

    Gene ID: 180430, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ifd-2
    Official Full Name
    Intermediate filament protein ifd-2
    Primary source
    WormBase:WBGene00002058
    Locus tag
    CELE_F25E2.4
    See related
    AllianceGenome:WB:WBGene00002058
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including heterochromatin formation; nucleus organization; and protein localization to nuclear envelope. Predicted to be located in cytoplasm and intermediate filament. Predicted to be active in nuclear envelope and nuclear lamina. Is expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); ectodermal dysplasia (multiple); hair disease (multiple); intrinsic cardiomyopathy (multiple); and myopathy (multiple). Orthologous to several human genes including DES (desmin); GFAP (glial fibrillary acidic protein); and INA (internexin neuronal intermediate filament protein alpha). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ifd-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (813854..815929, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Acyl-CoA thioesterase II Neighboring gene ncRNA Neighboring gene Smad protein daf-3 Neighboring gene ANAPC4_WD40 domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Intermediate filaments associate with aggresome-like structures in proteostressed C. elegans neurons and influence large vesicle extrusions as exophers. Arnold ML, et al. Nat Commun, 2023 Jul 24. PMID 37488107, Free PMC Article
    2. Promiscuous Dimerization Between the Caenorhabditis elegans IF Proteins and a Hypothesis to Explain How Multiple IFs Persist Over Evolutionary Time. Karabinos A, et al. J Mol Evol, 2019 Sep. PMID 31407015
    3. Intermediate filament (IF) proteins IFA-1 and IFB-1 represent a basic heteropolymeric IF cytoskeleton of nematodes: A molecular phylogeny of nematode IFs. Karabinos A. Gene, 2019 Apr 15. PMID 30641223
    4. Intermediate filament network perturbation in the C. elegans intestine causes systemic dysfunctions. Geisler F, et al. Elife, 2023 Jun 7. PMID 37283438, Free PMC Article
    5. Analysis of the novel excretory cell expressed ECP-1 protein and its proposed ECP-1/IFC-2 fusion protein EXC-2 in the nematode Caenorhabditis elegans. Karabinos A, et al. Gene Expr Patterns, 2019 Dec. PMID 31207388

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear envelope organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear pore localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear lamina IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Intermediate filament protein ifd-2
    NP_508160.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      813854..815929 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075759.7 → NP_508160.1  Intermediate filament protein ifd-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508160.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19782
      Conserved Domains (1) summary
      pfam00038
      Location:55 → 402
      Filament; Intermediate filament protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19782.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous