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    nac-1 Sodium-dependent low-affinity dicarboxylate transporter 1 [ Caenorhabditis elegans ]

    Gene ID: 181585, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nac-1
    Official Full Name
    Sodium-dependent low-affinity dicarboxylate transporter 1
    Primary source
    WormBase:WBGene00003517
    Locus tag
    CELE_F31F6.6
    See related
    AllianceGenome:WB:WBGene00003517
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables low-affinity sodium:dicarboxylate symporter activity and succinate transmembrane transporter activity. Involved in succinate transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in alimentary system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 25. Orthologous to several human genes including SLC13A2 (solute carrier family 13 member 2) and SLC13A5 (solute carrier family 13 member 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nac-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    11
    Sequence:
    Chromosome: X; NC_003284.9 (14895145..14898449)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene SSD domain-containing protein Neighboring gene Lipase Neighboring gene beta-N-acetylhexosaminidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and functional characteristics of two sodium-coupled dicarboxylate transporters (ceNaDC1 and ceNaDC2) from Caenorhabditis elegans and their relevance to life span. Fei YJ, et al. J Biol Chem, 2003 Feb 21. PMID 12480943
    2. Relevance of NAC-2, an Na+-coupled citrate transporter, to life span, body size and fat content in Caenorhabditis elegans. Fei YJ, et al. Biochem J, 2004 Apr 1. PMID 14678010, Free PMC Article
    3. Comparative analysis of Drosophila melanogaster and Caenorhabditis elegans gene expression experiments in the European Soyuz flights to the International Space Station. Leandro LJ, et al. Adv Space Res, 2007 Apr. PMID 18084631, Free PMC Article
    4. Dietary restriction in C. elegans: from rate-of-living effects to nutrient sensing pathways. Walker G, et al. Mech Ageing Dev, 2005 Sep. PMID 15896824
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. structural and functional characteristics of two sodium-coupled dicarboxylate transporters and their relevance to life span.
      Title: Structural and functional characteristics of two sodium-coupled dicarboxylate transporters (ceNaDC1 and ceNaDC2) from Caenorhabditis elegans and their relevance to life span.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables citrate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables low-affinity sodium:dicarboxylate symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables succinate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in citrate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in succinate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in succinate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in succinate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Sodium-dependent low-affinity dicarboxylate transporter 1
    NP_510473.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14895145..14898449
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078072.6 → NP_510473.2  Sodium-dependent low-affinity dicarboxylate transporter 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510473.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86R86, Q93655
      Conserved Domains (2) summary
      COG0471
      Location:19 → 547
      CitT; Di- and tricarboxylate transporter [Carbohydrate transport and metabolism]
      cd01115
      Location:45 → 544
      SLC13_permease; Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93655.3

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