cnk-1 Connector enhancer of kinase suppressor of ras [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cnk-1
Official Full Name: Connector enhancer of kinase suppressor of ras
Primary source: WormBase:WBGene00000564
Locus tag: CELE_R01H10.8
See related: AllianceGenome:WB:WBGene00000564
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be located in cytoplasm and membrane. Human ortholog(s) of this gene implicated in syndromic X-linked mental retardation Hough type. Orthologous to several human genes including CNKSR2 (connector enhancer of kinase suppressor of Ras 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cnk-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 13

Sequence:: Chromosome: III; NC_003281.10 (10271257..10278579)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Review highlights the implication of CNK and KSR in a novel mechanism regulating RAS-mediated RAF activation.
Title: KSR and CNK: two scaffolds regulating RAS-mediated RAF activation.
CNK promotes Raf phosphorylation/activation through membrane localization
Title: Caenorhabditis elegans CNK-1 promotes Raf activation but is not essential for Ras/Raf signaling.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS3-187 (e-PCR)
- UniSTS:242031

R01H10.8 (e-PCR)
- UniSTS:305870

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Connector enhancer of kinase suppressor of ras

NP_001391083.1

Partially confirmed by transcript evidence

NP_499274.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

10271257..10278579

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066873.7 → NP_499274.3 Connector enhancer of kinase suppressor of ras [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499274.3

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EEW9

Conserved Domains (6) summary

smart00454
Location:53 → 119

SAM; Sterile alpha motif

cd00992
Location:267 → 337

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00169
Location:636 → 736

PH; PH domain

pfam10534
Location:129 → 219

CRIC_ras_sig; Connector enhancer of kinase suppressor of ras

cl15755
Location:53 → 118

SAM_superfamily; SAM (Sterile alpha motif )

cl17171
Location:636 → 731

PH-like; Pleckstrin homology-like domain
NM_001404166.1 → NP_001391083.1 Connector enhancer of kinase suppressor of ras [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8D9I9L4