ZK1058.3 putative galactose-1-phosphate uridylyltransferase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ZK1058.3
Official Full Name: putative galactose-1-phosphate uridylyltransferase
Primary source: WormBase:WBGene00014203
Locus tag: CELE_ZK1058.3
See related: AllianceGenome:WB:WBGene00014203
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable UDP-glucose:hexose-1-phosphate uridylyltransferase activity. Predicted to be involved in galactose catabolic process via UDP-galactose. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in classic galactosemia. Orthologous to human GALT (galactose-1-phosphate uridylyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ZK1058.3 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (3918869..3920712)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK1058.3 (e-PCR)
- UniSTS:313667

ZK1058.4 (e-PCR)
- UniSTS:306605

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in galactose catabolic process via UDP-galactose	IBA Inferred from Biological aspect of Ancestor more info
involved_in galactose metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: putative galactose-1-phosphate uridylyltransferase

NP_497789.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

3918869..3920712

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065388.7 → NP_497789.1 putative galactose-1-phosphate uridylyltransferase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497789.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q27536

Conserved Domains (2) summary

PRK11720
Location:8 → 347

PRK11720; galactose-1-phosphate uridylyltransferase; Provisional

cd00608
Location:8 → 342

GalT; Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme ...