npr-8 G-protein coupled receptors family 1 profile domain-containing protein;putative G-protein coupled receptor npr-8 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: npr-8
Official Full Name: G-protein coupled receptors family 1 profile domain-containing protein;putative G-protein coupled receptor npr-8
Primary source: WormBase:WBGene00016984
Locus tag: CELE_C56G3.1
See related: AllianceGenome:WB:WBGene00016984
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable neuropeptide Y receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See npr-8 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 9

Sequence:: Chromosome: X; NC_003284.9 (7377302..7388377)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NPR-8 controls the dynamics of cuticle structure in response to infection, likely through its regulation of cuticular collagen genes which, in turn, affects the nematode's defense.
Title: Neuronal GPCR NPR-8 regulates C. elegans defense against pathogen infection.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C56G3.1 (e-PCR)
- UniSTS:309453

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide Y receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: G-protein coupled receptors family 1 profile domain-containing protein;putative G-protein coupled receptor npr-8

NP_001367458.1

Confirmed by transcript evidence

NP_741834.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

7377302..7388377

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001381023.2 → NP_001367458.1 putative G-protein coupled receptor npr-8 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18904

Conserved Domains (1) summary

cd15203
Location:62 → 399

7tmA_NPYR-like; neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_171723.7 → NP_741834.1 G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741834.1

Status: REVIEWED

UniProtKB/TrEMBL

G8JY12

Conserved Domains (1) summary

cd15203
Location:82 → 419

7tmA_NPYR-like; neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors