gtf-2E2 Transcription initiation factor IIE subunit beta [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gtf-2E2
Official Full Name: Transcription initiation factor IIE subunit beta
Primary source: WormBase:WBGene00010054
Locus tag: CELE_F54D5.11
See related: AllianceGenome:WB:WBGene00010054
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II complex binding activity. Involved in transcription initiation at RNA polymerase II promoter. Part of transcription factor TFIIE complex. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 6. Orthologous to human GTF2E2 (general transcription factor IIE subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gtf-2E2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 5

Sequence:: Chromosome: II; NC_003280.10 (11540773..11542495, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F54D5.11 (e-PCR)
- UniSTS:314445

F54D5.9 (e-PCR)
- UniSTS:311776

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II complex binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to TFIIH-class transcription factor complex binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in transcription initiation at RNA polymerase II promoter	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation at RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription initiation at RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIIE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIE complex	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIIE complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: Transcription initiation factor IIE subunit beta

NP_496466.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

11540773..11542495 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064065.10 → NP_496466.1 Transcription initiation factor IIE subunit beta [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496466.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EG47

Conserved Domains (1) summary

cd07977
Location:70 → 147

TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity