ife-4 Eukaryotic translation initiation factor 4E-4 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ife-4
Official Full Name: Eukaryotic translation initiation factor 4E-4
Primary source: WormBase:WBGene00002062
Locus tag: CELE_C05D9.5
See related: AllianceGenome:WB:WBGene00002062
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA 7-methylguanosine cap binding activity. Predicted to be involved in translational initiation. Predicted to be part of eukaryotic translation initiation factor 4F complex. Is expressed in several structures, including nervous system; non-striated muscle; reproductive system; somatic cell; and somatic gonad precursor. Orthologous to human EIF4E2 (eukaryotic translation initiation factor 4E family member 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ife-4 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 4

Sequence:: Chromosome: X; NC_003284.9 (1104212..1106251)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

microRNA-mediated translation repression through GYF-1 and IFE-4 in C. elegans development.
Title: microRNA-mediated translation repression through GYF-1 and IFE-4 in C. elegans development.
IFE4 is expressed in pharyngeal and tail neurons, body wall muscle, spermatheca, and vulva, and has a role in egg-laying
Title: Translation of a small subset of Caenorhabditis elegans mRNAs is dependent on a specific eukaryotic translation initiation factor 4E isoform.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C05D9.5 (e-PCR)
- UniSTS:318996

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA 7-methylguanosine cap binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA 7-methylguanosine cap binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA 7-methylguanosine cap binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
NOT involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of eukaryotic translation initiation factor 4F complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Eukaryotic translation initiation factor 4E-4

NP_508210.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

1104212..1106251

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_075809.5 → NP_508210.1 Eukaryotic translation initiation factor 4E-4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508210.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22888

Conserved Domains (1) summary

pfam01652
Location:35 → 190

IF4E; Eukaryotic initiation factor 4E