U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    rad-54.L DNA repair and recombination protein RAD54-like [ Caenorhabditis elegans ]

    Gene ID: 172728, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    rad-54.L
    Official Full Name
    DNA repair and recombination protein RAD54-like
    Primary source
    WormBase:WBGene00004298
    Locus tag
    CELE_W06D4.6
    See related
    AllianceGenome:WB:WBGene00004298
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables ATP-dependent activity, acting on DNA. Predicted to be involved in double-strand break repair via synthesis-dependent strand annealing and reciprocal meiotic recombination. Located in nucleus. Human ortholog(s) of this gene implicated in breast cancer; disease of cellular proliferation; non-Hodgkin lymphoma; and pancreatic cancer. Orthologous to human RAD54L (RAD54 like). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See rad-54.L in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    17
    Sequence:
    Chromosome: I; NC_003279.8 (9065079..9070264)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene BAR domain-containing protein Neighboring gene Protein arginine N-methyltransferase 7 Neighboring gene PX domain-containing protein Neighboring gene Abi_C domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A new partial loss of function allele of rad-54.L. Akerib CC, et al. MicroPubl Biol, 2022. PMID 36247323, Free PMC Article
    2. NER and HR pathways act sequentially to promote UV-C-induced germ cell apoptosis in Caenorhabditis elegans. Stergiou L, et al. Cell Death Differ, 2011 May. PMID 21151025, Free PMC Article
    3. Disparate roles for C. elegans DNA translocase paralogs RAD-54.L and RAD-54.B in meiotic prophase germ cells. Yamaya K, et al. Nucleic Acids Res, 2023 Sep 22. PMID 37548405, Free PMC Article
    4. me98 is a new allele of rad-54. Roelens B, et al. MicroPubl Biol, 2019 Apr 26. PMID 32550460, Free PMC Article
    5. REC-1 and HIM-5 distribute meiotic crossovers and function redundantly in meiotic double-strand break formation in Caenorhabditis elegans. Chung G, et al. Genes Dev, 2015 Sep 15. PMID 26385965, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Disparate roles for C. elegans DNA translocase paralogs RAD-54.L and RAD-54.B in meiotic prophase germ cells.
      Title: Disparate roles for C. elegans DNA translocase paralogs RAD-54.L and RAD-54.B in meiotic prophase germ cells.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent activity, acting on DNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA translocase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via synthesis-dependent strand annealing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    DNA repair and recombination protein RAD54-like
    NP_492438.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9065079..9070264
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060037.5 → NP_492438.1  DNA repair and recombination protein RAD54-like [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492438.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEN6
      Conserved Domains (3) summary
      cd00046
      Location:226 → 376
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:205 → 513
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:546 → 662
      Helicase_C; Helicase conserved C-terminal domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools