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    gpa-11 Guanine nucleotide-binding protein alpha-11 subunit [ Caenorhabditis elegans ]

    Gene ID: 173759, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gpa-11
    Official Full Name
    Guanine nucleotide-binding protein alpha-11 subunit
    Primary source
    WormBase:WBGene00001673
    Locus tag
    CELE_C16A11.1
    See related
    AllianceGenome:WB:WBGene00001673
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in determination of adult lifespan and serotonin receptor signaling pathway. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in ganglia. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gpa-11 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (4247197..4255577)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene CCDC93 N-terminal domain-containing protein;DUF4200 domain-containing protein Neighboring gene SH2 domain-containing protein Neighboring gene C-type lectin domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Feeding status and serotonin rapidly and reversibly modulate a Caenorhabditis elegans chemosensory circuit. Chao MY, et al. Proc Natl Acad Sci U S A, 2004 Oct 26. PMID 15492222, Free PMC Article
    2. DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis. Sendoel A, et al. Nat Cell Biol, 2014 Aug. PMID 25064737
    3. Signaling proteins that regulate NaCl [corrected] chemotaxis responses modulate longevity in C. elegans. Lans H, et al. Ann N Y Acad Sci, 2009 Jul. PMID 19686212
    4. Reverse genetics by chemical mutagenesis in Caenorhabditis elegans. Jansen G, et al. Nat Genet, 1997 Sep. PMID 9288111
    5. unc-42 regulates the expression of ASH terminal fate markers. Wood J, et al. MicroPubl Biol, 2019 May 15. PMID 32550468, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein beta/gamma-subunit complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables guanyl nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in serotonin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Guanine nucleotide-binding protein alpha-11 subunit
    NP_001254088.1
    • Confirmed by transcript evidence
    NP_001254089.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      4247197..4255577
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267159.1 → NP_001254088.1  Guanine nucleotide-binding protein alpha-11 subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254088.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76584
      Conserved Domains (2) summary
      cd00066
      Location:194 → 523
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
      smart00275
      Location:173 → 527
      G_alpha; G protein alpha subunit

    2. NM_001267160.2 → NP_001254089.1  Guanine nucleotide-binding protein alpha-11 subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254089.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F0IWT4, O76584
      Conserved Domains (2) summary
      cd00066
      Location:28 → 357
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
      smart00275
      Location:7 → 361
      G_alpha; G protein alpha subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76584.2

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