mec-3 Mechanosensory protein 3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mec-3
Official Full Name: Mechanosensory protein 3
Primary source: WormBase:WBGene00003167
Locus tag: CELE_F01D4.6
See related: AllianceGenome:WB:WBGene00003167
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and transcription coactivator activity. Involved in several processes, including mechanosensory behavior; neuron projection organization; and positive regulation of transcription by RNA polymerase II. Part of RNA polymerase II transcription regulator complex. Is expressed in VA neuron; head neurons; mechanosensory neurons; ventral nerve cord; and vulva. Orthologous to human LHX1 (LIM homeobox 1) and LHX5 (LIM homeobox 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mec-3 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 8

Sequence:: Chromosome: IV; NC_003282.8 (10458816..10461867, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MBL-1 and EEL-1 affect the splicing and protein levels of MEC-3 to control dendrite complexity.
Title: MBL-1 and EEL-1 affect the splicing and protein levels of MEC-3 to control dendrite complexity.
Data show that sem-4 indirectly modulates mec-3 expression through its repression of egl-5 and that this negative regulation is required for proper determination of neuronal fates.
Title: The Caenorhabditis elegans spalt-like gene sem-4 restricts touch cell fate by repressing the selector Hox gene egl-5 and the effector gene mec-3.
A sequence in the mec-3 upstream region has been identified that, when present in high copy extrachromosomal arrays, causes the ALM touch receptor neurons to migrate aberrantly and causes PLM touch receptor neuron axonal defects.
Title: High copy arrays containing a sequence upstream of mec-3 alter cell migration and axonal morphology in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F01D4.6 (e-PCR)
- UniSTS:313998

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in behavior	IEA Inferred from Electronic Annotation more info
involved_in mechanosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Mechanosensory protein 3

NP_001023111.1

Confirmed by transcript evidence

NP_001129852.1

Confirmed by transcript evidence

NP_001343802.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

10458816..10461867 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027940.5 → NP_001023111.1 Mechanosensory protein 3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023111.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B3GWD3, O02240, P09088, Q7YTQ4

Conserved Domains (3) summary

pfam00046
Location:220 → 273

Homeobox; Homeobox domain

pfam00412
Location:29 → 84

LIM; LIM domain

cl02475
Location:89 → 135

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001356932.4 → NP_001343802.1 Mechanosensory protein 3 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C378

Conserved Domains (2) summary

cl02475
Location:72 → 118

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

pfam00046
Location:203 → 256

Homeobox; Homeobox domain
NM_001136380.4 → NP_001129852.1 Mechanosensory protein 3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001129852.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P09088

Conserved Domains (2) summary

pfam00046
Location:177 → 230

Homeobox; Homeobox domain

cl02475
Location:46 → 92

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers