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    istr-1 IST1 homolog [ Caenorhabditis elegans ]

    Gene ID: 179737, updated on 9-Dec-2024

    Summary

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    Official Symbol
    istr-1
    Official Full Name
    IST1 homolog
    Primary source
    WormBase:WBGene00010736
    Locus tag
    CELE_K10C8.3
    See related
    AllianceGenome:WB:WBGene00010736
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in protein localization. Is expressed in intestine; nervous system; and pharynx. Orthologous to human IST1 (IST1 factor associated with ESCRT-III). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See istr-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (12697858..12704269)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene 3'-5' exoribonuclease parn-1 Neighboring gene Uncharacterized protein Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene F-box domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ist1 regulates ESCRT-III assembly and function during multivesicular endosome biogenesis in Caenorhabditis elegans embryos. Frankel EB, et al. Nat Commun, 2017 Nov 13. PMID 29129923, Free PMC Article
    2. The ESCRT machinery directs quality control over inner nuclear membrane architecture. Shankar R, et al. Cell Rep, 2022 Jan 18. PMID 35045304, Free PMC Article
    3. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article
    4. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    5. A protein domain-based interactome network for C. elegans early embryogenesis. Boxem M, et al. Cell, 2008 Aug 8. PMID 18692475, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    IST1 homolog
    NP_001122974.1
    • Partially confirmed by transcript evidence
    NP_001122975.1
    • Confirmed by transcript evidence
    NP_506170.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12697858..12704269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073769.7 → NP_506170.2  IST1 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506170.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECX8
      Conserved Domains (1) summary
      pfam03398
      Location:13 → 180
      Ist1; Regulator of Vps4 activity in the MVB pathway

    2. NM_001129503.3 → NP_001122975.1  IST1 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122975.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDV6
      Conserved Domains (1) summary
      pfam03398
      Location:13 → 180
      Ist1; Regulator of Vps4 activity in the MVB pathway

    3. NM_001129502.4 → NP_001122974.1  IST1 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122974.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5Z2T4
    Nucleotide Protein
    Heading Accession and Version

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