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    pri-2 DNA primase large subunit [ Caenorhabditis elegans ]

    Gene ID: 173122, updated on 14-Nov-2024

    Summary

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    Official Symbol
    pri-2
    Official Full Name
    DNA primase large subunit
    Primary source
    WormBase:WBGene00004181
    Locus tag
    CELE_W02D9.1
    See related
    AllianceGenome:WB:WBGene00004181
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 4 iron, 4 sulfur cluster binding activity; DNA binding activity; and metal ion binding activity. Involved in positive regulation of nematode male tail tip morphogenesis. Predicted to be part of alpha DNA polymerase:primase complex. Orthologous to human PRIM2 (DNA primase subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See pri-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (12528304..12532135, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Mitochondrial transcription termination factor family protein Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene Protein YIPF Neighboring gene HMG box domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Subunits of the DNA polymerase alpha-primase complex promote Notch-mediated proliferation with discrete and shared functions in C. elegans germline. Yoon DS, et al. FEBS J, 2018 Jul. PMID 29775245, Free PMC Article
    2. The unfolded protein response of the endoplasmic reticulum protects Caenorhabditis elegans against DNA damage caused by stalled replication forks. Xu J, et al. G3 (Bethesda), 2024 Apr 3. PMID 38267027, Free PMC Article
    3. DNA replication defects delay cell division and disrupt cell polarity in early Caenorhabditis elegans embryos. Encalada SE, et al. Dev Biol, 2000 Dec 15. PMID 11112326
    4. A bow-tie genetic architecture for morphogenesis suggested by a genome-wide RNAi screen in Caenorhabditis elegans. Nelson MD, et al. PLoS Genet, 2011 Mar. PMID 21408209, Free PMC Article
    5. A targeted RNAi screen for genes involved in chromosome morphogenesis and nuclear organization in the Caenorhabditis elegans germline. Colaiácovo MP, et al. Genetics, 2002 Sep. PMID 12242227, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The findings suggest that the subunits of the DNA polymerase alpha-primase complex exhibit both discrete and shared functions in GLP-1/Notch or PUF-mediated germ cell dynamics in C. elegans.
      Title: Subunits of the DNA polymerase alpha-primase complex promote Notch-mediated proliferation with discrete and shared functions in C. elegans germline.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication, synthesis of primer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication, synthesis of primer IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of alpha DNA polymerase:primase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of alpha DNA polymerase:primase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA primase large subunit
    NP_001251922.1
    • Confirmed by transcript evidence
    NP_001251923.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      12528304..12532135 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001264993.2 → NP_001251922.1  DNA primase large subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001251922.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O02334
      Conserved Domains (1) summary
      cd07322
      Location:43 → 475
      PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL

    2. NM_001264994.3 → NP_001251923.1  DNA primase large subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001251923.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D7SFP4
      Conserved Domains (1) summary
      cd07322
      Location:3 → 294
      PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O02334.2

    Gene LinkOut

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