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    lmp-1 LAMP family protein lmp-1 [ Caenorhabditis elegans ]

    Gene ID: 180912, updated on 2-Nov-2024

    Summary

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    Official Symbol
    lmp-1
    Official Full Name
    LAMP family protein lmp-1
    Primary source
    WormBase:WBGene00003053
    Locus tag
    CELE_C03B1.12
    See related
    AllianceGenome:WB:WBGene00003053
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in establishment of protein localization to organelle. Located in cytoplasmic vesicle and lysosomal membrane. Is expressed in coelomocyte; germ line; intestine; and pharynx. Human ortholog(s) of this gene implicated in Danon disease and hypertrophic cardiomyopathy. Orthologous to human LAMP2 (lysosomal associated membrane protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See lmp-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    4
    Sequence:
    Chromosome: X; NC_003284.9 (6376459..6377684, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene tRNA-Trp Neighboring gene CHCH domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene B-cell receptor CD22-like Neighboring gene Ig-like domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and molecular-genetic characterization of a LAMP/CD68-like protein from Caenorhabditis elegans. Kostich M, et al. J Cell Sci, 2000 Jul. PMID 10862717
    2. The lysosomal membrane protein SCAV-3 maintains lysosome integrity and adult longevity. Li Y, et al. J Cell Biol, 2016 Oct 24. PMID 27810910, Free PMC Article
    3. Spaceflight affects neuronal morphology and alters transcellular degradation of neuronal debris in adult Caenorhabditis elegans. Laranjeiro R, et al. iScience, 2021 Feb 19. PMID 33659873, Free PMC Article
    4. Normal formation of a subset of intestinal granules in Caenorhabditis elegans requires ATP-binding cassette transporters HAF-4 and HAF-9, which are highly homologous to human lysosomal peptide transporter TAP-like. Kawai H, et al. Mol Biol Cell, 2009 Jun. PMID 19403699, Free PMC Article
    5. The C. elegans P4-ATPase TAT-1 regulates lysosome biogenesis and endocytosis. Ruaud AF, et al. Traffic, 2009 Jan. PMID 18939953

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in establishment of protein localization to organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in gut granule membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    LAMP family protein lmp-1
    NP_509072.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      6376459..6377684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076671.8 → NP_509072.1  LAMP family protein lmp-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509072.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q11117
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q11117.1

    Gene LinkOut

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