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    ubql-1 Ubiquilin [ Caenorhabditis elegans ]

    Gene ID: 172434, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ubql-1
    Official Full Name
    Ubiquilin
    Primary source
    WormBase:WBGene00008852
    Locus tag
    CELE_F15C11.2
    See related
    AllianceGenome:WB:WBGene00008852
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable polyubiquitin modification-dependent protein binding activity. Involved in ERAD pathway; negative regulation of double-strand break repair via homologous recombination; and protein export from nucleus. Predicted to be active in cytosol. Is expressed in hypodermis; intestine; and pharynx. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 15. Orthologous to several human genes including UBQLN1 (ubiquilin 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ubql-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    12
    Sequence:
    Chromosome: I; NC_003279.8 (7021972..7029076)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein disulfide-isomerase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Suppression of polyglutamine-induced toxicity in cell and animal models of Huntington's disease by ubiquilin. Wang H, et al. Hum Mol Genet, 2006 Mar 15. PMID 16461334
    2. The polyphenol quercetin protects from glucotoxicity depending on the aggresome in Caenorhabditis elegans. Civelek M, et al. Eur J Nutr, 2020 Mar. PMID 30706126
    3. UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors. Jachimowicz RD, et al. Cell, 2019 Jan 24. PMID 30612738
    4. Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD. Lim PJ, et al. J Cell Biol, 2009 Oct 19. PMID 19822669, Free PMC Article
    5. AKIR-1 regulates proteasome subcellular function in Caenorhabditis elegans. Pispa J, et al. iScience, 2023 Oct 20. PMID 37767001, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein export from nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ubiquilin
    NP_740883.1
    • Confirmed by transcript evidence
    NP_740884.1
    • Confirmed by transcript evidence
    NP_740885.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7021972..7029076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170895.6 → NP_740885.1  Ubiquilin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740885.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EG66
      Conserved Domains (2) summary
      cd01808
      Location:8 → 79
      hPLIC_N; Ubiquitin-like domain of hPLIC-1 and hPLIC2
      smart00213
      Location:8 → 79
      UBQ; Ubiquitin homologues

    2. NM_171839.4 → NP_740884.1  Ubiquilin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740884.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EC78
      Conserved Domains (3) summary
      cd01808
      Location:8 → 79
      hPLIC_N; Ubiquitin-like domain of hPLIC-1 and hPLIC2
      smart00213
      Location:8 → 79
      UBQ; Ubiquitin homologues
      cd14399
      Location:443 → 482
      UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins

    3. NM_170894.5 → NP_740883.1  Ubiquilin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740883.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EC78, G5EFF7, G5EG66
      Conserved Domains (3) summary
      cd01808
      Location:8 → 79
      hPLIC_N; Ubiquitin-like domain of hPLIC-1 and hPLIC2
      cd14399
      Location:461 → 500
      UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins
      cl28408
      Location:18 → 372
      UBQ; Ubiquitin homologues
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EFF7.1

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