ada-2 SANT domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ada-2
Official Full Name: SANT domain-containing protein
Primary source: WormBase:WBGene00017967
Locus tag: CELE_F32A5.1
See related: AllianceGenome:WB:WBGene00017967
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable chromatin binding activity and transcription coactivator activity. Predicted to be involved in chromatin remodeling and regulation of transcription by RNA polymerase II. Predicted to be part of SAGA-type complex. Predicted to be active in nucleus. Orthologous to human TADA2B (transcriptional adaptor 2B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ada-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 8

Sequence:: Chromosome: II; NC_003280.10 (7252259..7255735)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F32A5.1 (e-PCR)
- UniSTS:310070

F32A5.7 (e-PCR)
- UniSTS:320954

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of SAGA-type complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: SANT domain-containing protein

NP_001022133.1

Confirmed by transcript evidence

NP_001022134.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

7252259..7255735

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026962.3 → NP_001022133.1 SANT domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022133.1

Status: REVIEWED

UniProtKB/TrEMBL

Q19953

Conserved Domains (2) summary

COG5114
Location:24 → 126

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

cd02335
Location:22 → 69

ZZ_ADA2; Zinc finger, ZZ type. Zinc finger present in ADA2, a putative transcriptional adaptor, and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
NM_001026963.5 → NP_001022134.1 SANT domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022134.1

Status: REVIEWED

UniProtKB/TrEMBL

Q5DX44

Conserved Domains (2) summary

COG5114
Location:11 → 113

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

cd02335
Location:9 → 56

ZZ_ADA2; Zinc finger, ZZ type. Zinc finger present in ADA2, a putative transcriptional adaptor, and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.