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    chd-1 DNA helicase [ Caenorhabditis elegans ]

    Gene ID: 172432, updated on 2-Nov-2024

    Summary

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    Official Symbol
    chd-1
    Official Full Name
    DNA helicase
    Primary source
    WormBase:WBGene00010369
    Locus tag
    CELE_H06O01.2
    See related
    AllianceGenome:WB:WBGene00010369
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable several functions, including ATP hydrolysis activity; ATP-dependent chromatin remodeler activity; and histone binding activity. Predicted to be involved in nucleosome organization. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed widely. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma; developmental and epileptic encephalopathy 94; and prostate cancer. Orthologous to several human genes including CHD1 (chromodomain helicase DNA binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See chd-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    11
    Sequence:
    Chromosome: I; NC_003279.8 (7009060..7015223, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene AbLIM_anchor domain-containing protein Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Protein ctg-1 Neighboring gene ncRNA Neighboring gene Protein disulfide-isomerase Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The chromatin remodeling protein CHD-1 and the EFL-1/DPL-1 transcription factor cooperatively down regulate CDK-2 to control SAS-6 levels and centriole number. Iyer J, et al. PLoS Genet, 2022 Apr. PMID 35377871, Free PMC Article
    2. Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants. O'Rourke SM, et al. PLoS Genet, 2007 Aug. PMID 17676955, Free PMC Article
    3. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA helicase
    NP_491994.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7009060..7015223 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059593.7 → NP_491994.2  DNA helicase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491994.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17909
      Conserved Domains (6) summary
      cd00024
      Location:232 → 276
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd00046
      Location:427 → 569
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:408 → 688
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:710 → 825
      Helicase_C; Helicase conserved C-terminal domain
      pfam00385
      Location:312 → 362
      Chromo; Chromo (CHRromatin Organization MOdifier) domain
      pfam13907
      Location:1289 → 1379
      DUF4208; Domain of unknown function (DUF4208)
    Nucleotide Protein
    Heading Accession and Version

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