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    dcp-66 Transcription factor dcp-66 [ Caenorhabditis elegans ]

    Gene ID: 172507, updated on 2-Nov-2024

    Summary

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    Official Symbol
    dcp-66
    Official Full Name
    Transcription factor dcp-66
    Primary source
    WormBase:WBGene00000938
    Locus tag
    CELE_C26C6.5
    See related
    AllianceGenome:WB:WBGene00000938
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in chromatin organization; mitochondrial unfolded protein response; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of NuRD complex. Is expressed in body wall musculature; neurons; pharynx; and tail. Human ortholog(s) of this gene implicated in GAND syndrome. Orthologous to several human genes including GATAD2B (GATA zinc finger domain containing 2B). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See dcp-66 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (7536104..7542159, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Guanine nucleotide-binding protein G(o) subunit alpha Neighboring gene Zinc metalloproteinase nas-36 Neighboring gene Nucleotide-diphospho-sugar transferase domain-containing protein Neighboring gene ncRNA Neighboring gene DUF4604 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Divergent regulatory roles of NuRD chromatin remodeling complex subunits GATAD2 and CHD4 in Caenorhabditis elegans. Golden NL, et al. Genetics, 2022 May 5. PMID 35323946, Free PMC Article
    2. Distinct regulatory elements mediate similar expression patterns in the excretory cell of Caenorhabditis elegans. Zhao Z, et al. J Biol Chem, 2005 Nov 18. PMID 16159881
    3. NuRD mediates mitochondrial stress-induced longevity via chromatin remodeling in response to acetyl-CoA level. Zhu D, et al. Sci Adv, 2020 Jul. PMID 32789178, Free PMC Article
    4. Members of the NODE (Nanog and Oct4-associated deacetylase) complex and SOX-2 promote the initiation of a natural cellular reprogramming event in vivo. Kagias K, et al. Proc Natl Acad Sci U S A, 2012 Apr 24. PMID 22493276, Free PMC Article
    5. SIN-3 functions through multi-protein interaction to regulate apoptosis, autophagy, and longevity in Caenorhabditis elegans. Konwar C, et al. Sci Rep, 2022 Jun 22. PMID 35732652, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of cis-elements from pgp-12 and DCP-66 show that distinct regulatory elements are able to mediate similar expression patterns
      Title: Distinct regulatory elements mediate similar expression patterns in the excretory cell of Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NuRD complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuRD complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Transcription factor dcp-66
    NP_492111.3
    • Confirmed by transcript evidence
    NP_871831.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7536104..7542159 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_182031.6 → NP_871831.3  Transcription factor dcp-66 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871831.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ECM2, G5ED89

    2. NM_059710.8 → NP_492111.3  Transcription factor dcp-66 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492111.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECM2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5ED89.2

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