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    Snrpa1 small nuclear ribonucleoprotein polypeptide A' [ Mus musculus (house mouse) ]

    Gene ID: 68981, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Snrpa1provided by MGI
    Official Full Name
    small nuclear ribonucleoprotein polypeptide A'provided by MGI
    Primary source
    MGI:MGI:1916231
    See related
    Ensembl:ENSMUSG00000030512 AllianceGenome:MGI:1916231
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500015N06Rik
    Summary
    Predicted to enable U2 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and spermatogenesis. Predicted to be located in nuclear speck. Predicted to be part of U2 snRNP; U2-type catalytic step 2 spliceosome; and U2-type precatalytic spliceosome. Is expressed in several structures, including central nervous system; hemolymphoid system; liver; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in connective tissue disease. Orthologous to human SNRPA1 (small nuclear ribonucleoprotein polypeptide A'). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 37.4), liver E14 (RPKM 25.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Snrpa1 in Genome Data Viewer
    Location:
    7 C; 7 35.47 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (65710084..65724335)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (66060336..66074587)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19072 Neighboring gene predicted gene 20684 Neighboring gene proprotein convertase subtilisin/kexin type 6 Neighboring gene STARR-seq mESC enhancer starr_19080 Neighboring gene predicted gene, 51486 Neighboring gene STARR-seq mESC enhancer starr_19081 Neighboring gene STARR-positive B cell enhancer ABC_E1088 Neighboring gene STARR-seq mESC enhancer starr_19082 Neighboring gene selenoprotein S Neighboring gene STARR-positive B cell enhancer ABC_E10440 Neighboring gene chondroitin sulfate synthase 1 Neighboring gene predicted gene, 23042

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning the cDNA for murine U2 snRNP-A' gene and its differential expression in lymphocyte development. Antica M, et al. Immunol Lett, 2002 Jul 3. PMID 12036604
    2. Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy. Bäumer D, et al. PLoS Genet, 2009 Dec. PMID 20019802, Free PMC Article
    3. Genetic mapping of putative Chrna7 and Luzp2 neuronal transcriptional enhancers due to impact of a transgene-insertion and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman syndromes. Stefan M, et al. BMC Genomics, 2005 Nov 9. PMID 16280085, Free PMC Article
    4. The periphilin 1-like BFAR isoform 3 is highly expressed in transcriptionally silent oocytes and involved in RNA metabolism. Mrowiec K, et al. Biochim Biophys Acta Mol Cell Res, 2021 Sep. PMID 34175335
    5. STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells. Jin L, et al. Nat Commun, 2020 Nov 23. PMID 33230114, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cloning the cDNA for murine U2 snRNP-A' gene and its differential expression in lymphocyte development
      Title: Cloning the cDNA for murine U2 snRNP-A' gene and its differential expression in lymphocyte development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC6298, MGC25531

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables U2 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables U2 snRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type catalytic step 2 spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of U2-type precatalytic spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    U2 small nuclear ribonucleoprotein A'
    Names
    U2 snRNP A'

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021336.4 → NP_067311.4  U2 small nuclear ribonucleoprotein A'

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AC148973, AK153502
      Consensus CDS
      CCDS21342.1
      UniProtKB/Swiss-Prot
      P57784, Q3U7R8, Q8K2W4, Q91YW1, Q9JKQ3
      Related
      ENSMUSP00000117947.2, ENSMUST00000153609.8
      Conserved Domains (2) summary
      sd00031
      Location:22 → 43
      LRR_1; leucine-rich repeat [structural motif]
      pfam14580
      Location:1 → 175
      LRR_9; Leucine-rich repeat

    RNA

    1. NR_152094.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC148973, AK005256, D18388
      Related
      ENSMUST00000032723.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      65710084..65724335
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P57784.2 GenPept UniProtKB/Swiss-Prot:P57784

    Gene LinkOut

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