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    gem-4 C2 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178108, updated on 2-Nov-2024

    Summary

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    Official Symbol
    gem-4
    Official Full Name
    C2 domain-containing protein
    Primary source
    WormBase:WBGene00001577
    Locus tag
    CELE_T12A7.1
    See related
    AllianceGenome:WB:WBGene00001577
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium-dependent phospholipid binding activity. Predicted to be involved in cellular response to calcium ion. Predicted to be active in plasma membrane. Is expressed in several structures, including Z2; Z3; head mesodermal cell; hermaphrodite gonad; and somatic gonad precursor. Orthologous to several human genes including CPNE5 (copine 5) and CPNE9 (copine family member 9). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See gem-4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (11745640..11748689)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene Glycine Rich Secreted Protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential regulation of TRPM channels governs electrolyte homeostasis in the C. elegans intestine. Teramoto T, et al. Cell Metab, 2005 May. PMID 16054081, Free PMC Article
    2. The promotion of gonadal cell divisions by the Caenorhabditis elegans TRPM cation channel GON-2 is antagonized by GEM-4 copine. Church DL, et al. Genetics, 2003 Oct. PMID 14573470, Free PMC Article
    3. Shank is a dose-dependent regulator of Ca(v)1 calcium current and CREB target expression. Pym E, et al. Elife, 2017 May 6. PMID 28477407, Free PMC Article
    4. Transgenerational inheritance of sexual attractiveness via small RNAs enhances evolvability in C. elegans. Toker IA, et al. Dev Cell, 2022 Feb 7. PMID 35134343, Free PMC Article
    5. Cell-Specific mRNA Profiling of the Caenorhabditis elegans Somatic Gonadal Precursor Cells Identifies Suites of Sex-Biased and Gonad-Enriched Transcripts. Kroetz MB, et al. G3 (Bethesda), 2015 Oct 23. PMID 26497144, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to calcium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    C2 domain-containing protein
    NP_502225.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11745640..11748689
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069824.4 → NP_502225.1  C2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502225.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22422
      Conserved Domains (3) summary
      cd04047
      Location:175 → 289
      C2B_Copine; C2 domain second repeat in Copine
      cd04048
      Location:16 → 149
      C2A_Copine; C2 domain first repeat in Copine
      pfam07002
      Location:349 → 573
      Copine; Copine
    Nucleotide Protein
    Heading Accession and Version

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