sgca-1 CADG domain-containing protein;Dystroglycan-type cadherin-like domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sgca-1
Official Full Name: CADG domain-containing protein;Dystroglycan-type cadherin-like domain-containing protein
Primary source: WormBase:WBGene00019227
Locus tag: CELE_H22K11.4
See related: AllianceGenome:WB:WBGene00019227
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable calcium ion binding activity. Located in striated muscle dense body. Is expressed in anal depressor muscle; anal sphincter muscle; body wall musculature; and vulval muscle. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2D; muscular dystrophy; and myoclonic dystonia 11. Orthologous to human SGCA (sarcoglycan alpha) and SGCE (sarcoglycan epsilon). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sgca-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 10

Sequence:: Chromosome: X; NC_003284.9 (6787256..6789548, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

H22K11.4 (e-PCR)
- UniSTS:312668

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of sarcoglycan complex	IBA Inferred from Biological aspect of Ancestor more info
part_of sarcoglycan complex	IEA Inferred from Electronic Annotation more info
located_in striated muscle dense body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CADG domain-containing protein;Dystroglycan-type cadherin-like domain-containing protein

NP_001360086.1

Confirmed by transcript evidence

NP_001360087.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

6787256..6789548 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001373338.3 → NP_001360086.1 Dystroglycan-type cadherin-like domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

H2L0C3

Conserved Domains (2) summary

smart00736
Location:29 → 118

CADG; Dystroglycan-type cadherin-like domains

pfam05510
Location:28 → 320

Sarcoglycan_2; Sarcoglycan alpha/epsilon
NM_001373339.3 → NP_001360087.1 CADG domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q1XFY3