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    klp-11 Kinesin-like protein [ Caenorhabditis elegans ]

    Gene ID: 177685, updated on 9-Dec-2024

    Summary

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    Official Symbol
    klp-11
    Official Full Name
    Kinesin-like protein
    Primary source
    WormBase:WBGene00002222
    Locus tag
    CELE_F20C5.2
    See related
    AllianceGenome:WB:WBGene00002222
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables microtubule motor activity. Involved in microtubule-based movement. Part of axonemal heterotrimeric kinesin-II complex. Is expressed in amphid neurons; dorsal nerve cord; inner labial neurons; phasmid neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in retinitis pigmentosa 89. Orthologous to human KIF3B (kinesin family member 3B) and KIF3C (kinesin family member 3C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See klp-11 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    14
    Sequence:
    Chromosome: IV; NC_003282.8 (8756735..8762066, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Poly(ADP-ribose) glycohydrolase 1;poly(ADP-ribose) glycohydrolase Neighboring gene ncRNA Neighboring gene Enlarged germline granules protein 1 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Cell cycle control protein 50A Neighboring gene PACT_coil_coil domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. How kinesin-2 forms a stalk. Vukajlovic M, et al. Mol Biol Cell, 2011 Nov. PMID 21917588, Free PMC Article
    2. Functional differentiation of cooperating kinesin-2 motors orchestrates cargo import and transport in C. elegans cilia. Prevo B, et al. Nat Cell Biol, 2015 Dec. PMID 26523365
    3. C. elegans KLP-11/OSM-3/KAP-1: orthologs of the sea urchin kinesin-II, and mouse KIF3A/KIFB/KAP3 kinesin complexes. Khan ML, et al. DNA Res, 2000 Apr 28. PMID 10819327
    4. Regulation of a heterodimeric kinesin-2 through an unprocessive motor domain that is turned processive by its partner. Brunnbauer M, et al. Proc Natl Acad Sci U S A, 2010 Jun 8. PMID 20498083, Free PMC Article
    5. Kinesin-2 motors adapt their stepping behavior for processive transport on axonemes and microtubules. Stepp WL, et al. EMBO Rep, 2017 Nov. PMID 28887322, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The temperature dependence of kinesin motor-protein mechanochemistry.
      Title: The temperature dependence of kinesin motor-protein mechanochemistry.
    2. Kinesin-2 motors adapt their stepping behavior for processive transport on axonemes and microtubules.
      Title: Kinesin-2 motors adapt their stepping behavior for processive transport on axonemes and microtubules.
    3. Caenorhabditis elegans
      Title: Functional differentiation of cooperating kinesin-2 motors orchestrates cargo import and transport in C. elegans cilia.
    4. study demonstrates that heterodimerization of the two distinct motor domains KLP11 and KLP20 of kinesin-2 requires a dimerization seed of merely two heptads at the C terminus of the stalk
      Title: How kinesin-2 forms a stalk.
    5. provide several interdependent reasons for the heterodimerization of the kinesin-2 motor KLP11/KLP20 of Caenorhabditis elegans cilia.
      Title: Regulation of a heterodimeric kinesin-2 through an unprocessive motor domain that is turned processive by its partner.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of axonemal heterotrimeric kinesin-II complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Kinesin-like protein
    NP_001129854.3
    • Confirmed by transcript evidence
    NP_001129855.3
    • Confirmed by transcript evidence
    NP_001255330.2
    • Confirmed by transcript evidence
    NP_001369897.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8756735..8762066 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383153.2 → NP_001369897.1  Kinesin-like protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19633, Q9GV92
      Conserved Domains (2) summary
      TIGR02168
      Location:337 → 584
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl22853
      Location:12 → 343
      Motor_domain; Myosin and Kinesin motor domain

    2. NM_001136382.3 → NP_001129854.3  Kinesin-like protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129854.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3GWB6

    3. NM_001136383.3 → NP_001129855.3  Kinesin-like protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129855.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3GWB7

    4. NM_001268401.2 → NP_001255330.2  Kinesin-like protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255330.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E5QCG4
    Nucleotide Protein
    Heading Accession and Version

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