unc-43 Calcium/calmodulin-dependent protein kinase II association-domain domain-containing protein;Calcium/calmodulin-dependent protein kinase type II;calcium/calmodulin-dependent protein kinase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-43
Official Full Name: Calcium/calmodulin-dependent protein kinase II association-domain domain-containing protein;Calcium/calmodulin-dependent protein kinase type II;calcium/calmodulin-dependent protein kinase
Primary source: WormBase:WBGene00006779
Locus tag: CELE_K11E8.1
See related: AllianceGenome:WB:WBGene00006779
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables calcium/calmodulin-dependent protein kinase activity; identical protein binding activity; and transmembrane transporter binding activity. Involved in MAPK cascade; medium-term memory; and positive regulation of gene expression. Acts upstream of or within serotonin biosynthetic process. Located in axon cytoplasm. Is expressed in several structures, including copulatory spicule; gonadal sheath cell; nervous system; oocyte; and postcloacal sensillum. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; autosomal dominant intellectual developmental disorder 53; autosomal dominant intellectual developmental disorder 54; and autosomal recessive intellectual developmental disorder 63. Orthologous to several human genes including CAMK2D (calcium/calmodulin dependent protein kinase II delta). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See unc-43 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 24

Sequence:: Chromosome: IV; NC_003282.8 (10324254..10350217, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CaMKII mediates sexually dimorphic synaptic transmission at neuromuscular junctions in C. elegans.
Title: CaMKII mediates sexually dimorphic synaptic transmission at neuromuscular junctions in C. elegans.
UNC-43/CaMKII-triggered anterograde signals recruit GABAARs to mediate inhibitory synaptic transmission and plasticity at C. elegans NMJs.
Title: UNC-43/CaMKII-triggered anterograde signals recruit GABA(A)Rs to mediate inhibitory synaptic transmission and plasticity at C. elegans NMJs.
MAPK signaling and a mobile scaffold complex regulate AMPA receptor transport to modulate synaptic strength.
Title: MAPK signaling and a mobile scaffold complex regulate AMPA receptor transport to modulate synaptic strength.
these data implicate the importance of subunit stoichiometry as another regulatory mechanism of PKA activity and lipid metabolism.
Title: Protein Kinase A Subunit Balance Regulates Lipid Metabolism in Caenorhabditis elegans and Mammalian Adipocytes.
Results with unc-43 mutants reveal a new function for CaM kinase II in blocking the regulated exocytosis of dense core vesicles before they are transported into axons.
Title: A novel CaM kinase II pathway controls the location of neuropeptide release from Caenorhabditis elegans motor neurons.
identified UNC-2/UNC-36 voltage-gated calcium channels and UNC-43/CaMKII as regulators of C. elegans synaptogenesis
Title: The Caenorhabditis elegans voltage-gated calcium channel subunits UNC-2 and UNC-36 and the calcium-dependent kinase UNC-43/CaMKII regulate neuromuscular junction morphology.
UNC-43 functions cell-autonomously in ADF neurons to generate training-dependent enhancement in neuronal activity and tph-1 transcription, and this cell-autonomous function of UNC-43 is required for learning.
Title: A neuronal signaling pathway of CaMKII and Gqα regulates experience-dependent transcription of tph-1.
Studies sugget the effect of CaMKII autophosphorylation at Thr286 on calmodulin trapping that it stabilises the active state and therefore makes the high-affinity binding site accessible.
Title: Structural analysis and stochastic modelling suggest a mechanism for calmodulin trapping by CaMKII.
The activity of egg-laying defective protein (EGL)-2 is promoted by calcium/calmodulin-dependent protein kinase II (CaMKII) unc-43.
Title: The effects of transient starvation persist through direct interactions between CaMKII and ether-a-go-go K+ channels in C. elegans males.
Reuslts identify four genes to be required for the quercetin derived lifespan extension in C. elegans, namely age-1, daf-2, unc-43 and sek-1.
Title: Quercetin mediated lifespan extension in Caenorhabditis elegans is modulated by age-1, daf-2, sek-1 and unc-43.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y43C5B.1 (e-PCR)
- UniSTS:320396

K11E8.1 (e-PCR)
- UniSTS:319915

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium/calmodulin-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium/calmodulin-dependent protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium/calmodulin-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in medium-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuronal synaptic plasticity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within serotonin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Calcium/calmodulin-dependent protein kinase II association-domain domain-containing protein;Calcium/calmodulin-dependent protein kinase type II;calcium/calmodulin-dependent protein kinase

NP_001023293.2

Partially confirmed by transcript evidence

NP_001023298.1

Confirmed by transcript evidence

NP_001023304.1

Confirmed by transcript evidence

NP_001122788.1

Confirmed by transcript evidence

NP_001122789.1

Confirmed by transcript evidence

NP_001129863.1

Confirmed by transcript evidence

NP_001255480.1

Confirmed by transcript evidence

NP_001255481.1

Confirmed by transcript evidence

NP_001255482.1

Confirmed by transcript evidence

NP_001255483.1

Confirmed by transcript evidence

NP_001359633.1

Confirmed by transcript evidence

NP_001366992.1

Confirmed by transcript evidence

NP_001366993.1

Confirmed by transcript evidence

NP_001366994.1

Confirmed by transcript evidence

NP_001366996.1

Confirmed by transcript evidence

NP_001366997.1

Confirmed by transcript evidence

NP_001369918.1

Partially confirmed by transcript evidence

NP_001379280.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

10324254..10350217 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001028133.5 → NP_001023304.1 Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023304.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O62305

Conserved Domains (1) summary

pfam08332
Location:176 → 300

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
NM_001028122.5 → NP_001023293.2 Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023293.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O62305

Conserved Domains (1) summary

pfam08332
Location:97 → 221

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
NM_001380439.3 → NP_001366993.1 Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

cd14086
Location:10 → 300

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:387 → 511

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
NM_001129317.5 → NP_001122789.1 Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122789.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O62305

Conserved Domains (1) summary

pfam08332
Location:136 → 260

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
NM_001028127.6 → NP_001023298.1 Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023298.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O62305

Conserved Domains (3) summary

smart00220
Location:12 → 269

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14086
Location:10 → 300

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:385 → 509

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
NM_001380442.1 → NP_001366992.1 Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cd14086
Location:10 → 300

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
NM_001129316.4 → NP_001122788.1 Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122788.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O62305

Conserved Domains (1) summary

pfam08332
Location:82 → 206

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
NM_001372918.3 → NP_001359633.1 Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

cd14086
Location:10 → 300

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:400 → 524

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
NM_001392387.1 → NP_001379280.1 Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

cd14086
Location:10 → 300

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:349 → 473

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
NM_001380440.3 → NP_001366994.1 Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

cd14086
Location:10 → 300

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:438 → 562

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
NM_001268551.3 → NP_001255480.1 calcium/calmodulin-dependent protein kinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255480.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EDZ5

Conserved Domains (2) summary

cd14086
Location:120 → 410

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:548 → 672

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
NM_001380441.3 → NP_001366996.1 Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cd14086
Location:10 → 298

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
NM_001380443.1 → NP_001366997.1 Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cd14086
Location:10 → 300

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
NM_001268552.3 → NP_001255481.1 Calcium/calmodulin-dependent protein kinase II association-domain domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255481.1

Status: REVIEWED

UniProtKB/TrEMBL

F5GUA8

Conserved Domains (1) summary

pfam08332
Location:133 → 257

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
NM_001136391.4 → NP_001129863.1 Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001129863.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O62305

Conserved Domains (1) summary

pfam08332
Location:83 → 207

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
NM_001268553.3 → NP_001255482.1 Calcium/calmodulin-dependent protein kinase II association-domain domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255482.1

Status: REVIEWED

UniProtKB/TrEMBL

F5GUA9

Conserved Domains (1) summary

pfam08332
Location:165 → 289

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
NM_001268554.3 → NP_001255483.1 Calcium/calmodulin-dependent protein kinase II association-domain domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255483.1

Status: REVIEWED

UniProtKB/TrEMBL

E7EM33

Conserved Domains (1) summary

cl09109
Location:1 → 94

NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
NM_001383187.2 → NP_001369918.1 Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cl21453
Location:10 → 136

PKc_like; Protein Kinases, catalytic domain