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    cls-1 Protein CLASP-1 [ Caenorhabditis elegans ]

    Gene ID: 176064, updated on 2-Nov-2024

    Summary

    Official Symbol
    cls-1
    Official Full Name
    Protein CLASP-1
    Primary source
    WormBase:WBGene00015580
    Locus tag
    CELE_C07H6.3
    See related
    AllianceGenome:WB:WBGene00015580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable microtubule binding activity. Involved in microtubule cytoskeleton organization and positive regulation of microtubule depolymerization. Predicted to be located in cytoplasm and microtubule. Predicted to be active in basal cortex; kinetochore; and microtubule cytoskeleton. Is expressed in several structures, including nervous system; pharyngeal-intestinal valve; pharynx; rectal gland cell; and reproductive system. Orthologous to several human genes including CLASP2 (cytoplasmic linker associated protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See cls-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    16
    Sequence:
    Chromosome: III; NC_003281.10 (7508178..7515285)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class Z Neighboring gene U2 snRNP-associated SURP motif-containing protein Neighboring gene Telomere length regulation protein clk-2 Neighboring gene RRM domain-containing protein Neighboring gene E3 ubiquitin-protein ligase PPP1R11

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in astral microtubule organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of mitotic spindle localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment of mitotic spindle localization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of microtubule polymerization or depolymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of supramolecular fiber organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spindle elongation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in basal cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    Protein CLASP-1
    NP_498649.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7508178..7515285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066248.5NP_498649.1  Protein CLASP-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498649.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95YF0
      Conserved Domains (1) summary
      pfam12348
      Location:379591
      CLASP_N; CLASP N terminal