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    deb-1 Vinculin [ Caenorhabditis elegans ]

    Gene ID: 177482, updated on 2-Nov-2024

    Summary

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    Official Symbol
    deb-1
    Official Full Name
    Vinculin
    Primary source
    WormBase:WBGene00000942
    Locus tag
    CELE_ZC477.9
    See related
    AllianceGenome:WB:WBGene00000942
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    A structural constituent of cytoskeleton. Involved in positive regulation of ovulation. Located in several cellular components, including cytoskeleton; dense body; and striated muscle dense body. Is expressed in gonad and muscle cell. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1W; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 15. Orthologous to human VCL (vinculin). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See deb-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    18
    Sequence:
    Chromosome: IV; NC_003282.8 (7085215..7094266, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene MS Related Protein Neighboring gene TruB_N domain-containing protein Neighboring gene ncRNA Neighboring gene Small ribosomal subunit protein eS4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The basal component of the nematode dense-body is vinculin. Barstead RJ, et al. J Biol Chem, 1989 Jun 15. PMID 2498337
    2. The worm turns to vinculin function. Fyrberg E. Curr Biol, 1992 Jan. PMID 15336057
    3. Vinculin is essential for muscle function in the nematode. Barstead RJ, et al. J Cell Biol, 1991 Aug. PMID 1907975, Free PMC Article
    4. Pairing of homologous chromosomes in C. elegans meiosis requires DEB-1 - an orthologue of mammalian vinculin. Rohožková J, et al. Nucleus, 2019 Dec. PMID 31068058, Free PMC Article
    5. Ultra-structural time-course study in the C. elegans model for Duchenne muscular dystrophy highlights a crucial role for sarcomere-anchoring structures and sarcolemma integrity in the earliest steps of the muscle degeneration process. Brouilly N, et al. Hum Mol Genet, 2015 Nov 15. PMID 26358775

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The data identify DEB-1 as a new player regulating chromosome dynamics and pairing during meiotic prophase I.
      Title: Pairing of homologous chromosomes in C. elegans meiosis requires DEB-1 - an orthologue of mammalian vinculin.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of ovulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cell-cell contact zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dense body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in striated muscle dense body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Vinculin
    NP_001293743.1
    • Confirmed by transcript evidence
    NP_001293744.1
    • Confirmed by transcript evidence
    NP_001293745.1
    • Confirmed by transcript evidence
    NP_001368387.1
    • Confirmed by transcript evidence
    NP_001368388.1
    • Confirmed by transcript evidence
    NP_501104.2
    • Confirmed by transcript evidence
    NP_501105.2
    • Confirmed by transcript evidence
    NP_741437.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7085215..7094266 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068703.7 → NP_501104.2  Vinculin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501104.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P19826
      Conserved Domains (1) summary
      pfam01044
      Location:63 → 1009
      Vinculin; Vinculin family

    2. NM_171374.6 → NP_741437.1  Vinculin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741437.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MPS2
      Conserved Domains (1) summary
      pfam01044
      Location:63 → 998
      Vinculin; Vinculin family

    3. NM_068704.7 → NP_501105.2  Vinculin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501105.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BI31
      Conserved Domains (1) summary
      pfam01044
      Location:46 → 368
      Vinculin; Vinculin family

    4. NM_001306814.4 → NP_001293743.1  Vinculin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293743.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P19826, Q8MPS2, Q9BI31, Q9BI32, V6CJ36, V6CK82, V6CLG2, V6CLK1, V6CLL2
      Conserved Domains (1) summary
      pfam01044
      Location:143 → 1089
      Vinculin; Vinculin family

    5. NM_001306815.3 → NP_001293744.1  Vinculin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293744.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CK82
      Conserved Domains (1) summary
      pfam01044
      Location:143 → 1078
      Vinculin; Vinculin family

    6. NM_001306816.3 → NP_001293745.1  Vinculin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293745.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLL2
      Conserved Domains (1) summary
      pfam01044
      Location:46 → 357
      Vinculin; Vinculin family

    7. NM_001380304.1 → NP_001368387.1  Vinculin [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam01044
      Location:37 → 220
      Vinculin; Vinculin family

    8. NM_001380305.1 → NP_001368388.1  Vinculin [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam01044
      Location:37 → 231
      Vinculin; Vinculin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19826.2

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