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    unc-36 VWFA domain-containing protein;Voltage-dependent calcium channel unc-36 [ Caenorhabditis elegans ]

    Gene ID: 176155, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-36
    Official Full Name
    VWFA domain-containing protein;Voltage-dependent calcium channel unc-36
    Primary source
    WormBase:WBGene00006772
    Locus tag
    CELE_C50C3.9
    See related
    AllianceGenome:WB:WBGene00006772
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables calcium channel regulator activity; delayed rectifier potassium channel activity; and voltage-gated calcium channel activity. Involved in several processes, including egg-laying behavior; nematode pharyngeal pumping; and serotonin receptor signaling pathway. Located in endoplasmic reticulum membrane and plasma membrane. Part of voltage-gated calcium channel complex. Is expressed in alimentary muscle; body wall musculature; nervous system; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 110 and retinal cone dystrophy 4. Orthologous to several human genes including CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See unc-36 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    16
    Sequence:
    Chromosome: III; NC_003281.10 (8193843..8201217, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene SPeCtrin Neighboring gene FBA_3 domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Synaptobrevin-like protein 5 Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Calcium: an insignificant thing. Frøkjaer-Jensen C, et al. Nat Neurosci, 2009 Oct. PMID 19783977, Free PMC Article
    2. Optical imaging of calcium transients in neurons and pharyngeal muscle of C. elegans. Kerr R, et al. Neuron, 2000 Jun. PMID 10896155
    3. A mutational analysis of Caenorhabditis elegans in space. Zhao Y, et al. Mutat Res, 2006 Oct 10. PMID 16765996
    4. EGL-36 Shaw channels regulate C. elegans egg-laying muscle activity. Elkes DA, et al. Neuron, 1997 Jul. PMID 9247272
    5. Using machine vision to analyze and classify Caenorhabditis elegans behavioral phenotypes quantitatively. Baek JH, et al. J Neurosci Methods, 2002 Jul 30. PMID 12191753

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. identified UNC-2/UNC-36 voltage-gated calcium channels and UNC-43/CaMKII as regulators of C. elegans synaptogenesis
      Title: The Caenorhabditis elegans voltage-gated calcium channel subunits UNC-2 and UNC-36 and the calcium-dependent kinase UNC-43/CaMKII regulate neuromuscular junction morphology.
    2. EGL-19, UNC-36, and CCB-1 underlie voltage-dependent calcium currents in C. elegans striated muscle.
      Title: The alpha1 subunit EGL-19, the alpha2/delta subunit UNC-36, and the beta subunit CCB-1 underlie voltage-dependent calcium currents in Caenorhabditis elegans striated muscle.
    3. central role for EGL-19 and UNC-36 in excitability and functional activity of the mechanosensory neurons
      Title: Effects of voltage-gated calcium channel subunit genes on calcium influx in cultured C. elegans mechanosensory neurons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium channel regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables delayed rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode pharyngeal pumping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in serotonin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of voltage-gated calcium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated calcium channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    VWFA domain-containing protein;Voltage-dependent calcium channel unc-36
    NP_001040851.1
    • Confirmed by transcript evidence
    NP_001040852.1
    • Confirmed by transcript evidence
    NP_001254955.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8193843..8201217 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268026.4 → NP_001254955.1  VWFA domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254955.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4S4A1
      Conserved Domains (4) summary
      cd01463
      Location:236 → 422
      vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
      pfam08399
      Location:95 → 221
      VWA_N; VWA N-terminal
      pfam08473
      Location:917 → 1178
      VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
      pfam02743
      Location:504 → 585
      dCache_1; Cache domain

    2. NM_001047386.6 → NP_001040851.1  Voltage-dependent calcium channel unc-36 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040851.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A9Z1J5, P34372, P34373, P34374
      Conserved Domains (3) summary
      cd01463
      Location:236 → 466
      vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
      pfam02743
      Location:548 → 606
      Cache_1; Cache domain
      pfam08399
      Location:95 → 221
      VWA_N; VWA N-terminal

    3. NM_001047387.4 → NP_001040852.1  Voltage-dependent calcium channel unc-36 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040852.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34374
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34374.2

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