U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    rrf-2 RNA-directed RNA polymerase [ Caenorhabditis elegans ]

    Gene ID: 173092, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    rrf-2
    Official Full Name
    RNA-directed RNA polymerase
    Primary source
    WormBase:WBGene00004509
    Locus tag
    CELE_M01G12.12
    See related
    AllianceGenome:WB:WBGene00004509
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA-dependent RNA polymerase activity. Acts upstream of or within IRE1-mediated unfolded protein response. Predicted to be part of nuclear RNA-directed RNA polymerase complex. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See rrf-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    21
    Sequence:
    Chromosome: I; NC_003279.8 (12098671..12106112, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Decapping nuclease Neighboring gene Decapping nuclease Neighboring gene Decapping nuclease Neighboring gene Decapping nuclease

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. On the role of RNA amplification in dsRNA-triggered gene silencing. Sijen T, et al. Cell, 2001 Nov 16. PMID 11719187
    2. Gene silencing: shrinking the black box of RNAi. Hunter CP. Curr Biol, 2000 Feb 24. PMID 10704407
    3. 26G endo-siRNAs regulate spermatogenic and zygotic gene expression in Caenorhabditis elegans. Han T, et al. Proc Natl Acad Sci U S A, 2009 Nov 3. PMID 19846761, Free PMC Article
    4. PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans. Batista PJ, et al. Mol Cell, 2008 Jul 11. PMID 18571452, Free PMC Article
    5. EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans. Smardon A, et al. Curr Biol, 2000 Feb 24. PMID 10704412

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA-dependent RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA-dependent RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA-dependent RNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within IRE1-mediated unfolded protein response HEP PubMed 
    involved_in RNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in siRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of nuclear RNA-directed RNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    RNA-directed RNA polymerase
    NP_493057.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      12098671..12106112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060656.5 → NP_493057.1  RNA-directed RNA polymerase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493057.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFA8
      Conserved Domains (1) summary
      pfam05183
      Location:464 → 1016
      RdRP; RNA dependent RNA polymerase
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools