pmt-1 Phosphoethanolamine N-methyltransferase 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pmt-1
Official Full Name: Phosphoethanolamine N-methyltransferase 1
Primary source: WormBase:WBGene00022781
Locus tag: CELE_ZK622.3
See related: AllianceGenome:WB:WBGene00022781
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables phosphoethanolamine N-methyltransferase activity. Involved in nematode larval development and phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-choline. Predicted to be located in cytosol. Is expressed in hypodermis. Used to study lipid metabolism disorder. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pmt-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 6

Sequence:: Chromosome: II; NC_003280.10 (5278090..5282517, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SAMS-1 and PMT-1 were shown to contribute to the homoeostasis of TG and PC levels in C. elegans, which would provide an important survival strategy under harsh environmental conditions.
Title: Contribution of sams-1 and pmt-1 to lipid homoeostasis in adult Caenorhabditis elegans.
Data show that phosphoethanolamine N-methyltransferase (PMT-1) only catalyses the conversion of phosphoethanolamine into phospho-monomethylethanolamine, in contrast with multifunctional enzymes from plants and Plasmodium.
Title: Phosphoethanolamine N-methyltransferase (PMT-1) catalyses the first reaction of a new pathway for phosphocholine biosynthesis in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK622.3 (e-PCR)
- UniSTS:310526

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoethanolamine N-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoethanolamine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in multicellular organismal reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-choline	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylcholine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: Phosphoethanolamine N-methyltransferase 1

NP_001379829.1

Confirmed by transcript evidence

NP_494990.2

Confirmed by transcript evidence

NP_494991.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

5278090..5282517 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062590.4 → NP_494991.1 Phosphoethanolamine N-methyltransferase 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_494991.1

Status: REVIEWED

UniProtKB/TrEMBL

H2KZF5

Conserved Domains (1) summary

PLN02336
Location:39 → 260

PLN02336; phosphoethanolamine N-methyltransferase
NM_062589.9 → NP_494990.2 Phosphoethanolamine N-methyltransferase 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_494990.2

Status: REVIEWED

UniProtKB/Swiss-Prot

H2KZF5, Q23552, Q86NB3

Conserved Domains (1) summary

PLN02336
Location:30 → 251

PLN02336; phosphoethanolamine N-methyltransferase
NM_001393066.1 → NP_001379829.1 Phosphoethanolamine N-methyltransferase 1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

PLN02336
Location:15 → 236

PLN02336; phosphoethanolamine N-methyltransferase