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    pole-4 Transcription factor CBF/NF-Y/archaeal histone domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175152, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pole-4
    Official Full Name
    Transcription factor CBF/NF-Y/archaeal histone domain-containing protein
    Primary source
    WormBase:WBGene00013150
    Locus tag
    CELE_Y53F4B.3
    See related
    AllianceGenome:WB:WBGene00013150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein heterodimerization activity. Predicted to be involved in DNA-templated DNA replication. Predicted to be part of epsilon DNA polymerase complex. Predicted to be active in nucleus. Orthologous to human POLE4 (DNA polymerase epsilon 4, accessory subunit). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See pole-4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003280.10 (14968633..14969354, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Elongation of very long chain fatty acids protein Neighboring gene 26S rRNA (cytosine-C(5))-methyltransferase nsun-5 Neighboring gene tRNA N(3)-methylcytidine methyltransferase Neighboring gene pseudo Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Synthetic Lethality between DNA Polymerase Epsilon and RTEL1 in Metazoan DNA Replication. Bellelli R, et al. Cell Rep, 2020 May 26. PMID 32460026, Free PMC Article
    2. C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates. Andersen EC, et al. Development, 2006 Jul. PMID 16774993
    3. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
    4. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
    5. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of epsilon DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Transcription factor CBF/NF-Y/archaeal histone domain-containing protein
    NP_497087.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      14968633..14969354 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064686.5 → NP_497087.1  Transcription factor CBF/NF-Y/archaeal histone domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497087.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NAC5
      Conserved Domains (1) summary
      COG5208
      Location:13 → 121
      HAP5; CCAAT-binding factor, subunit C [Transcription]
    Nucleotide Protein
    Heading Accession and Version

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